Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history

Abstract Shikonin and its derivatives extracted from Lithospermeae plants’ red roots have current applications in food and pharmaceutical industries. Previous studies have cloned some genes related to shikonin biosynthesis. However, most genes related to shikonin biosynthesis remain unclear, because...

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Autores principales:	Feng-Yao Wu, Cheng-Yi Tang, Yu-Min Guo, Zhuo-Wu Bian, Jiang-Yan Fu, Gui-Hua Lu, Jin-Liang Qi, Yan-Jun Pang, Yong-Hua Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/62f975e5c56442998aa746c2e5e2079d
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spelling	oai:doaj.org-article:62f975e5c56442998aa746c2e5e2079d2021-12-02T16:06:44ZTranscriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history10.1038/s41598-017-04750-12045-2322https://doaj.org/article/62f975e5c56442998aa746c2e5e2079d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04750-1https://doaj.org/toc/2045-2322Abstract Shikonin and its derivatives extracted from Lithospermeae plants’ red roots have current applications in food and pharmaceutical industries. Previous studies have cloned some genes related to shikonin biosynthesis. However, most genes related to shikonin biosynthesis remain unclear, because the lack of the genome/transcriptome of the Lithospermeae plants. Therefore, in order to provide a new understanding of shikonin biosynthesis, we obtained transcriptome data and unigenes expression profiles in three shikonin-producing Lithospermeae plants, i.e., Lithospermum erythrorhizon, Arnebia euchroma and Echium plantagineum. As a result, two unigenes (i.e., G10H and 12OPR) that are involved in “shikonin downstream biosynthesis” and “methyl jasmonate biosynthesis” were deemed to relate to shikonin biosynthesis in this study. Furthermore, we conducted a Lamiids phylogenetic model and identified orthologous unigenes under positive selection in above three Lithospermeae plants. The results indicated Boraginales was more relative to Solanales/Gentianales than to Lamiales.Feng-Yao WuCheng-Yi TangYu-Min GuoZhuo-Wu BianJiang-Yan FuGui-Hua LuJin-Liang QiYan-Jun PangYong-Hua YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Feng-Yao Wu Cheng-Yi Tang Yu-Min Guo Zhuo-Wu Bian Jiang-Yan Fu Gui-Hua Lu Jin-Liang Qi Yan-Jun Pang Yong-Hua Yang Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history
description	Abstract Shikonin and its derivatives extracted from Lithospermeae plants’ red roots have current applications in food and pharmaceutical industries. Previous studies have cloned some genes related to shikonin biosynthesis. However, most genes related to shikonin biosynthesis remain unclear, because the lack of the genome/transcriptome of the Lithospermeae plants. Therefore, in order to provide a new understanding of shikonin biosynthesis, we obtained transcriptome data and unigenes expression profiles in three shikonin-producing Lithospermeae plants, i.e., Lithospermum erythrorhizon, Arnebia euchroma and Echium plantagineum. As a result, two unigenes (i.e., G10H and 12OPR) that are involved in “shikonin downstream biosynthesis” and “methyl jasmonate biosynthesis” were deemed to relate to shikonin biosynthesis in this study. Furthermore, we conducted a Lamiids phylogenetic model and identified orthologous unigenes under positive selection in above three Lithospermeae plants. The results indicated Boraginales was more relative to Solanales/Gentianales than to Lamiales.
format	article
author	Feng-Yao Wu Cheng-Yi Tang Yu-Min Guo Zhuo-Wu Bian Jiang-Yan Fu Gui-Hua Lu Jin-Liang Qi Yan-Jun Pang Yong-Hua Yang
author_facet	Feng-Yao Wu Cheng-Yi Tang Yu-Min Guo Zhuo-Wu Bian Jiang-Yan Fu Gui-Hua Lu Jin-Liang Qi Yan-Jun Pang Yong-Hua Yang
author_sort	Feng-Yao Wu
title	Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history
title_short	Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history
title_full	Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history
title_fullStr	Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history
title_full_unstemmed	Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history
title_sort	transcriptome analysis explores genes related to shikonin biosynthesis in lithospermeae plants and provides insights into boraginales’ evolutionary history
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/62f975e5c56442998aa746c2e5e2079d
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Transcriptome analysis explores genes related to shikonin biosynthesis in Lithospermeae plants and provides insights into Boraginales’ evolutionary history

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