Plasmid-mediated metronidazole resistance in Clostridioides difficile

Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer met...

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Autores principales:	Ilse M. Boekhoud, Bastian V. H. Hornung, Eloisa Sevilla, Céline Harmanus, Ingrid M. J. G. Bos-Sanders, Elisabeth M. Terveer, Rosa Bolea, Jeroen Corver, Ed J. Kuijper, Wiep Klaas Smits
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/62feb273069b45dbbfbfc70da53d3cb5
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spelling	oai:doaj.org-article:62feb273069b45dbbfbfc70da53d3cb52021-12-02T14:40:27ZPlasmid-mediated metronidazole resistance in Clostridioides difficile10.1038/s41467-020-14382-12041-1723https://doaj.org/article/62feb273069b45dbbfbfc70da53d3cb52020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14382-1https://doaj.org/toc/2041-1723Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer metronidazole resistance.Ilse M. BoekhoudBastian V. H. HornungEloisa SevillaCéline HarmanusIngrid M. J. G. Bos-SandersElisabeth M. TerveerRosa BoleaJeroen CorverEd J. KuijperWiep Klaas SmitsNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ilse M. Boekhoud Bastian V. H. Hornung Eloisa Sevilla Céline Harmanus Ingrid M. J. G. Bos-Sanders Elisabeth M. Terveer Rosa Bolea Jeroen Corver Ed J. Kuijper Wiep Klaas Smits Plasmid-mediated metronidazole resistance in Clostridioides difficile
description	Cases of C. difficile (CD) resistant to metronidazole have been reported but the mechanism remains enigmatic. Here the authors identify a plasmid, which correlates with metronidazole resistance status in a large international collection of CD isolates, and demonstrate that the plasmid can confer metronidazole resistance.
format	article
author	Ilse M. Boekhoud Bastian V. H. Hornung Eloisa Sevilla Céline Harmanus Ingrid M. J. G. Bos-Sanders Elisabeth M. Terveer Rosa Bolea Jeroen Corver Ed J. Kuijper Wiep Klaas Smits
author_facet	Ilse M. Boekhoud Bastian V. H. Hornung Eloisa Sevilla Céline Harmanus Ingrid M. J. G. Bos-Sanders Elisabeth M. Terveer Rosa Bolea Jeroen Corver Ed J. Kuijper Wiep Klaas Smits
author_sort	Ilse M. Boekhoud
title	Plasmid-mediated metronidazole resistance in Clostridioides difficile
title_short	Plasmid-mediated metronidazole resistance in Clostridioides difficile
title_full	Plasmid-mediated metronidazole resistance in Clostridioides difficile
title_fullStr	Plasmid-mediated metronidazole resistance in Clostridioides difficile
title_full_unstemmed	Plasmid-mediated metronidazole resistance in Clostridioides difficile
title_sort	plasmid-mediated metronidazole resistance in clostridioides difficile
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/62feb273069b45dbbfbfc70da53d3cb5
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Plasmid-mediated metronidazole resistance in Clostridioides difficile

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