Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration

The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global...

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Autores principales:	Jongmin Kim, Yeo Jin Lee, Jae Yon Won
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	age-related macular degeneration retinal pigment epithelium Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/63002cd319d04f1db9e763315c734a39
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spelling	oai:doaj.org-article:63002cd319d04f1db9e763315c734a392021-11-25T17:55:12ZMolecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration10.3390/ijms2222122981422-00671661-6596https://doaj.org/article/63002cd319d04f1db9e763315c734a392021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12298https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.Jongmin KimYeo Jin LeeJae Yon WonMDPI AGarticleage-related macular degenerationretinal pigment epitheliumBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12298, p 12298 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	age-related macular degeneration retinal pigment epithelium Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	age-related macular degeneration retinal pigment epithelium Biology (General) QH301-705.5 Chemistry QD1-999 Jongmin Kim Yeo Jin Lee Jae Yon Won Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
description	The retinal pigment epithelium (RPE), situated upon Bruch’s membrane, plays multiple roles in the ocular system by interacting with photoreceptors and. Therefore, dysfunction of the RPE causes diseases related to vision loss, such as age-related macular degeneration (AMD). Despite AMD being a global cause of blindness, the pathogenesis remains unclear. Understanding the pathogenesis of AMD is the first step for its prevention and treatment. This review summarizes the common pathways of RPE dysfunction and their effect in AMD. Potential treatment strategies for AMD based on targeting the RPE have also been discussed.
format	article
author	Jongmin Kim Yeo Jin Lee Jae Yon Won
author_facet	Jongmin Kim Yeo Jin Lee Jae Yon Won
author_sort	Jongmin Kim
title	Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_short	Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_full	Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_fullStr	Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_full_unstemmed	Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration
title_sort	molecular mechanisms of retinal pigment epithelium dysfunction in age-related macular degeneration
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63002cd319d04f1db9e763315c734a39
work_keys_str_mv	AT jongminkim molecularmechanismsofretinalpigmentepitheliumdysfunctioninagerelatedmaculardegeneration AT yeojinlee molecularmechanismsofretinalpigmentepitheliumdysfunctioninagerelatedmaculardegeneration AT jaeyonwon molecularmechanismsofretinalpigmentepitheliumdysfunctioninagerelatedmaculardegeneration
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Molecular Mechanisms of Retinal Pigment Epithelium Dysfunction in Age-Related Macular Degeneration

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