New insights into the pathogenesis of Peyronie’s disease: A narrative review

Peyronie’s disease (PD) is a benign, progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea (TA) of the penis. This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines, cell signaling pathwa...

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Autores principales:	Denis V. Krakhotkin, Volodymyr A. Chernylovskyi, Alexandre Mottrie, Francesco Greco, Ruslan A. Bugaev
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Peyronie’s disease Cell signal pathway Penile curvature Myofibroblast Extracellular matrix Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/63027c0011324ed591921f849ee98e1d
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spelling	oai:doaj.org-article:63027c0011324ed591921f849ee98e1d2021-12-02T13:36:57ZNew insights into the pathogenesis of Peyronie’s disease: A narrative review2095-882X10.1016/j.cdtm.2020.06.001https://doaj.org/article/63027c0011324ed591921f849ee98e1d2020-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X20300608https://doaj.org/toc/2095-882XPeyronie’s disease (PD) is a benign, progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea (TA) of the penis. This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines, cell signaling pathways, biochemical mechanisms, genetic factors responsible for fibrogenesis. A growing body of literature has shown that PD is a chronically impaired, localized, wound healing process within the TA and the Smith space. It is caused by the influence of different pathological stimuli, most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features, imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP), and suppressed antioxidant systems during chronic inflammation. Other intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor-β1 signaling. The development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators.Denis V. KrakhotkinVolodymyr A. ChernylovskyiAlexandre MottrieFrancesco GrecoRuslan A. BugaevKeAi Communications Co., Ltd.articlePeyronie’s diseaseCell signal pathwayPenile curvatureMyofibroblastExtracellular matrixMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 6, Iss 3, Pp 165-181 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Peyronie’s disease Cell signal pathway Penile curvature Myofibroblast Extracellular matrix Medicine (General) R5-920
spellingShingle	Peyronie’s disease Cell signal pathway Penile curvature Myofibroblast Extracellular matrix Medicine (General) R5-920 Denis V. Krakhotkin Volodymyr A. Chernylovskyi Alexandre Mottrie Francesco Greco Ruslan A. Bugaev New insights into the pathogenesis of Peyronie’s disease: A narrative review
description	Peyronie’s disease (PD) is a benign, progressive fibrotic disorder characterized by scar or plaques within the tunica albuginea (TA) of the penis. This study provides new insights into the pathogenesis of PD based on data from different studies regarding the roles of cytokines, cell signaling pathways, biochemical mechanisms, genetic factors responsible for fibrogenesis. A growing body of literature has shown that PD is a chronically impaired, localized, wound healing process within the TA and the Smith space. It is caused by the influence of different pathological stimuli, most often the effects of mechanical stress during sexual intercourse in genetically sensitive individuals with unusual anatomical TA features, imbalanced matrix metalloproteinase/tissue inhibitor of metalloproteinase (MMP/TIMP), and suppressed antioxidant systems during chronic inflammation. Other intracellular signal cascades are activated during fibrosis along with low expression levels of their negative regulators and transforming growth factor-β1 signaling. The development of multikinase agents with minimal side effects that can block several signal cell pathways would significantly improve fibrosis in PD tissues by acting on common downstream mediators.
format	article
author	Denis V. Krakhotkin Volodymyr A. Chernylovskyi Alexandre Mottrie Francesco Greco Ruslan A. Bugaev
author_facet	Denis V. Krakhotkin Volodymyr A. Chernylovskyi Alexandre Mottrie Francesco Greco Ruslan A. Bugaev
author_sort	Denis V. Krakhotkin
title	New insights into the pathogenesis of Peyronie’s disease: A narrative review
title_short	New insights into the pathogenesis of Peyronie’s disease: A narrative review
title_full	New insights into the pathogenesis of Peyronie’s disease: A narrative review
title_fullStr	New insights into the pathogenesis of Peyronie’s disease: A narrative review
title_full_unstemmed	New insights into the pathogenesis of Peyronie’s disease: A narrative review
title_sort	new insights into the pathogenesis of peyronie’s disease: a narrative review
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/63027c0011324ed591921f849ee98e1d
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New insights into the pathogenesis of Peyronie’s disease: A narrative review

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