RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 in human adipocyte biology and body fat distributio...

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Autores principales:	Nellie Y. Loh, James E. N. Minchin, Katherine E. Pinnick, Manu Verma, Marijana Todorčević, Nathan Denton, Julia El-Sayed Moustafa, John P. Kemp, Celia L. Gregson, David M. Evans, Matt J. Neville, Kerrin S. Small, Mark I. McCarthy, Anubha Mahajan, John F. Rawls, Fredrik Karpe, Constantinos Christodoulides
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/63058441426945e38b49d38d86552953
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spelling	oai:doaj.org-article:63058441426945e38b49d38d865529532021-12-02T18:24:49ZRSPO3 impacts body fat distribution and regulates adipose cell biology in vitro10.1038/s41467-020-16592-z2041-1723https://doaj.org/article/63058441426945e38b49d38d865529532020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16592-zhttps://doaj.org/toc/2041-1723Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 in human adipocyte biology and body fat distribution in zebrafishNellie Y. LohJames E. N. MinchinKatherine E. PinnickManu VermaMarijana TodorčevićNathan DentonJulia El-Sayed MoustafaJohn P. KempCelia L. GregsonDavid M. EvansMatt J. NevilleKerrin S. SmallMark I. McCarthyAnubha MahajanJohn F. RawlsFredrik KarpeConstantinos ChristodoulidesNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nellie Y. Loh James E. N. Minchin Katherine E. Pinnick Manu Verma Marijana Todorčević Nathan Denton Julia El-Sayed Moustafa John P. Kemp Celia L. Gregson David M. Evans Matt J. Neville Kerrin S. Small Mark I. McCarthy Anubha Mahajan John F. Rawls Fredrik Karpe Constantinos Christodoulides RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
description	Genetic variants at the RSPO3 locus are associated with waist-to-hip ratio (adjusted for BMI). Here, Loh et al. describe two independent RSPO3 signals that associate with body fat distribution, perform fine-mapping and explore the function of RSPO3 in human adipocyte biology and body fat distribution in zebrafish
format	article
author	Nellie Y. Loh James E. N. Minchin Katherine E. Pinnick Manu Verma Marijana Todorčević Nathan Denton Julia El-Sayed Moustafa John P. Kemp Celia L. Gregson David M. Evans Matt J. Neville Kerrin S. Small Mark I. McCarthy Anubha Mahajan John F. Rawls Fredrik Karpe Constantinos Christodoulides
author_facet	Nellie Y. Loh James E. N. Minchin Katherine E. Pinnick Manu Verma Marijana Todorčević Nathan Denton Julia El-Sayed Moustafa John P. Kemp Celia L. Gregson David M. Evans Matt J. Neville Kerrin S. Small Mark I. McCarthy Anubha Mahajan John F. Rawls Fredrik Karpe Constantinos Christodoulides
author_sort	Nellie Y. Loh
title	RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
title_short	RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
title_full	RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
title_fullStr	RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
title_full_unstemmed	RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro
title_sort	rspo3 impacts body fat distribution and regulates adipose cell biology in vitro
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/63058441426945e38b49d38d86552953
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RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro

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