Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases

The blood–brain barrier (BBB) is a vital structure for maintaining homeostasis between the blood and the brain in the central nervous system (CNS). Biomolecule exchange, ion balance, nutrition delivery, and toxic molecule prevention rely on the normal function of the BBB. The dysfunction and the dys...

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Autores principales:	Xingchi Chen, Chang Liu, Laureana Muok, Changchun Zeng, Yan Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	blood–brain barrier human pluripotent stem cells microfluidics three-dimensional model neurological disorders Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/6308038b27374d2fb68c93b5163297e0
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spelling	oai:doaj.org-article:6308038b27374d2fb68c93b5163297e02021-11-25T17:12:30ZDynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases10.3390/cells101131832073-4409https://doaj.org/article/6308038b27374d2fb68c93b5163297e02021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4409/10/11/3183https://doaj.org/toc/2073-4409The blood–brain barrier (BBB) is a vital structure for maintaining homeostasis between the blood and the brain in the central nervous system (CNS). Biomolecule exchange, ion balance, nutrition delivery, and toxic molecule prevention rely on the normal function of the BBB. The dysfunction and the dysregulation of the BBB leads to the progression of neurological disorders and neurodegeneration. Therefore, in vitro BBB models can facilitate the investigation for proper therapies. As the demand increases, it is urgent to develop a more efficient and more physiologically relevant BBB model. In this review, the development of the microfluidics platform for the applications in neuroscience is summarized. This article focuses on the characterizations of in vitro BBB models derived from human stem cells and discusses the development of various types of in vitro models. The microfluidics-based system and BBB-on-chip models should provide a better platform for high-throughput drug-screening and targeted delivery.Xingchi ChenChang LiuLaureana MuokChangchun ZengYan LiMDPI AGarticleblood–brain barrierhuman pluripotent stem cellsmicrofluidicsthree-dimensional modelneurological disordersBiology (General)QH301-705.5ENCells, Vol 10, Iss 3183, p 3183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood–brain barrier human pluripotent stem cells microfluidics three-dimensional model neurological disorders Biology (General) QH301-705.5
spellingShingle	blood–brain barrier human pluripotent stem cells microfluidics three-dimensional model neurological disorders Biology (General) QH301-705.5 Xingchi Chen Chang Liu Laureana Muok Changchun Zeng Yan Li Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases
description	The blood–brain barrier (BBB) is a vital structure for maintaining homeostasis between the blood and the brain in the central nervous system (CNS). Biomolecule exchange, ion balance, nutrition delivery, and toxic molecule prevention rely on the normal function of the BBB. The dysfunction and the dysregulation of the BBB leads to the progression of neurological disorders and neurodegeneration. Therefore, in vitro BBB models can facilitate the investigation for proper therapies. As the demand increases, it is urgent to develop a more efficient and more physiologically relevant BBB model. In this review, the development of the microfluidics platform for the applications in neuroscience is summarized. This article focuses on the characterizations of in vitro BBB models derived from human stem cells and discusses the development of various types of in vitro models. The microfluidics-based system and BBB-on-chip models should provide a better platform for high-throughput drug-screening and targeted delivery.
format	article
author	Xingchi Chen Chang Liu Laureana Muok Changchun Zeng Yan Li
author_facet	Xingchi Chen Chang Liu Laureana Muok Changchun Zeng Yan Li
author_sort	Xingchi Chen
title	Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases
title_short	Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases
title_full	Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases
title_fullStr	Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases
title_full_unstemmed	Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases
title_sort	dynamic 3d on-chip bbb model design, development, and applications in neurological diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6308038b27374d2fb68c93b5163297e0
work_keys_str_mv	AT xingchichen dynamic3donchipbbbmodeldesigndevelopmentandapplicationsinneurologicaldiseases AT changliu dynamic3donchipbbbmodeldesigndevelopmentandapplicationsinneurologicaldiseases AT laureanamuok dynamic3donchipbbbmodeldesigndevelopmentandapplicationsinneurologicaldiseases AT changchunzeng dynamic3donchipbbbmodeldesigndevelopmentandapplicationsinneurologicaldiseases AT yanli dynamic3donchipbbbmodeldesigndevelopmentandapplicationsinneurologicaldiseases
_version_	1718412592101195776

Dynamic 3D On-Chip BBB Model Design, Development, and Applications in Neurological Diseases

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