Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer

Abstract Recent studies have reported of an association between high serum apolipoprotein A1 (APOA1) levels and favorable prognosis in several malignancies, while the significance of apolipoprotein B (APOB) in cancer is less well-known. In this study, we analyzed the correlation between serum APOA1...

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Autores principales:	Päivi Sirniö, Juha P. Väyrynen, Kai Klintrup, Jyrki Mäkelä, Markus J. Mäkinen, Tuomo J. Karttunen, Anne Tuomisto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/630bba1648fa4f389f24a9278b72195e
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spelling	oai:doaj.org-article:630bba1648fa4f389f24a9278b72195e2021-12-02T12:32:04ZDecreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer10.1038/s41598-017-05415-92045-2322https://doaj.org/article/630bba1648fa4f389f24a9278b72195e2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05415-9https://doaj.org/toc/2045-2322Abstract Recent studies have reported of an association between high serum apolipoprotein A1 (APOA1) levels and favorable prognosis in several malignancies, while the significance of apolipoprotein B (APOB) in cancer is less well-known. In this study, we analyzed the correlation between serum APOA1 and APOB levels, and APOB/APOA1 ratio, and their associations with clinicopathologic parameters, the levels of twenty systemic inflammatory markers, and survival in 144 colorectal cancer (CRC) patients. We demonstrated that low serum APOA1 levels associated with advanced T-class and TNM-stage but low serum APOB levels did not significantly correlate with tumor characteristics. Serum APOA1 levels showed strong negative correlation with the markers of systemic inflammation including serum CRP and interleukin (IL)-8 levels and blood neutrophil count, whereas high serum APOB levels associated with high serum CCL2 levels. High APOA1 and APOB levels and low APOB/APOA1 ratio associated with improved cancer specific and overall survival. APOA1 had independent prognostic value in Cox regression analysis. In conclusion, low serum APOA1 levels are associated with advanced stage and systemic inflammation, while serum APOB does not significantly correlate with tumor stage. Serum APOA1 represents a promising additional prognostic parameter in CRC.Päivi SirniöJuha P. VäyrynenKai KlintrupJyrki MäkeläMarkus J. MäkinenTuomo J. KarttunenAnne TuomistoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Päivi Sirniö Juha P. Väyrynen Kai Klintrup Jyrki Mäkelä Markus J. Mäkinen Tuomo J. Karttunen Anne Tuomisto Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
description	Abstract Recent studies have reported of an association between high serum apolipoprotein A1 (APOA1) levels and favorable prognosis in several malignancies, while the significance of apolipoprotein B (APOB) in cancer is less well-known. In this study, we analyzed the correlation between serum APOA1 and APOB levels, and APOB/APOA1 ratio, and their associations with clinicopathologic parameters, the levels of twenty systemic inflammatory markers, and survival in 144 colorectal cancer (CRC) patients. We demonstrated that low serum APOA1 levels associated with advanced T-class and TNM-stage but low serum APOB levels did not significantly correlate with tumor characteristics. Serum APOA1 levels showed strong negative correlation with the markers of systemic inflammation including serum CRP and interleukin (IL)-8 levels and blood neutrophil count, whereas high serum APOB levels associated with high serum CCL2 levels. High APOA1 and APOB levels and low APOB/APOA1 ratio associated with improved cancer specific and overall survival. APOA1 had independent prognostic value in Cox regression analysis. In conclusion, low serum APOA1 levels are associated with advanced stage and systemic inflammation, while serum APOB does not significantly correlate with tumor stage. Serum APOA1 represents a promising additional prognostic parameter in CRC.
format	article
author	Päivi Sirniö Juha P. Väyrynen Kai Klintrup Jyrki Mäkelä Markus J. Mäkinen Tuomo J. Karttunen Anne Tuomisto
author_facet	Päivi Sirniö Juha P. Väyrynen Kai Klintrup Jyrki Mäkelä Markus J. Mäkinen Tuomo J. Karttunen Anne Tuomisto
author_sort	Päivi Sirniö
title	Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
title_short	Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
title_full	Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
title_fullStr	Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
title_full_unstemmed	Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
title_sort	decreased serum apolipoprotein a1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/630bba1648fa4f389f24a9278b72195e
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Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer

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