Clinical features of pediatric idiopathic intracranial hypertension

Daniel Agraz,1 Linda A Morgan,2 Samiksha Fouzdar Jain,1,2 Donny W Suh1,21College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA; 2Department of Pediatric Ophthalmology, Children’s Hospital and Medical Center, Omaha, NE, USAIntroduction: Adult idiopathic intracranial hyp...

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Autores principales:	Agraz D, Morgan LA, Fouzdar Jain S, Suh DW
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	idiopathic intracranial hypertension papilledema headache obesity Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/630d4e45e711496ebea3c32a4267df5f
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spelling	oai:doaj.org-article:630d4e45e711496ebea3c32a4267df5f2021-12-02T05:59:20ZClinical features of pediatric idiopathic intracranial hypertension1177-5483https://doaj.org/article/630d4e45e711496ebea3c32a4267df5f2019-05-01T00:00:00Zhttps://www.dovepress.com/clinical-features-of-pediatric-idiopathic-intracranial-hypertension-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Daniel Agraz,1 Linda A Morgan,2 Samiksha Fouzdar Jain,1,2 Donny W Suh1,21College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA; 2Department of Pediatric Ophthalmology, Children’s Hospital and Medical Center, Omaha, NE, USAIntroduction: Adult idiopathic intracranial hypertension (IIH) is often linked to obesity, however, causes of IIH in children are not well understood. This project identifies potential risk factors and features of pediatric IIH.Methods: This study consisted of a retrospective chart review of patients ages 5–17 years who were seen at a tertiary care children’s hospital and diagnosed with IIH. Diagnostic criteria included the presence of papilledema, normal neurological exam, normal neuroimaging, normal cerebrospinal fluid composition, and an opening pressure of a lumbar puncture >28 mmHg.Results: Of the 26 cases of IIH, 19 met all diagnostic criteria for this study, while seven patients were probable IIH, as they lacked papilledema. Intracranial pressure ranged from 28 to 66 mmHg, with a mean of 40.23 mmHg (±10.74). Overall, 50.0% (95% CI: 29.9–70.1%) of IIH patients were obese, with patients 12 years of age and younger exhibiting an overall obesity rate of 30.7% and patients 13 years of age and older having an obesity rate of 69.2%. The overall allergy rate in this IIH patient population was 46.2% (95% CI: 26.6–66.6%).Conclusion: Obesity appears to have no association with IIH in younger cases, but it is a more common feature in older children. An autoimmune component may play a role in pediatric IIH, given the high rate of atopy observed in this pediatric IIH patient cohort. Because a diagnosis of IIH can have an absence of optic nerve edema, taking a detailed history and performing a thorough examination are keys to diagnosing IIH in the pediatric population.Keywords: idiopathic intracranial hypertension, papilledema, headache, obesity  Agraz DMorgan LAFouzdar Jain SSuh DWDove Medical Pressarticleidiopathic intracranial hypertensionpapilledemaheadacheobesityOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 881-886 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic intracranial hypertension papilledema headache obesity Ophthalmology RE1-994
spellingShingle	idiopathic intracranial hypertension papilledema headache obesity Ophthalmology RE1-994 Agraz D Morgan LA Fouzdar Jain S Suh DW Clinical features of pediatric idiopathic intracranial hypertension
description	Daniel Agraz,1 Linda A Morgan,2 Samiksha Fouzdar Jain,1,2 Donny W Suh1,21College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA; 2Department of Pediatric Ophthalmology, Children’s Hospital and Medical Center, Omaha, NE, USAIntroduction: Adult idiopathic intracranial hypertension (IIH) is often linked to obesity, however, causes of IIH in children are not well understood. This project identifies potential risk factors and features of pediatric IIH.Methods: This study consisted of a retrospective chart review of patients ages 5–17 years who were seen at a tertiary care children’s hospital and diagnosed with IIH. Diagnostic criteria included the presence of papilledema, normal neurological exam, normal neuroimaging, normal cerebrospinal fluid composition, and an opening pressure of a lumbar puncture >28 mmHg.Results: Of the 26 cases of IIH, 19 met all diagnostic criteria for this study, while seven patients were probable IIH, as they lacked papilledema. Intracranial pressure ranged from 28 to 66 mmHg, with a mean of 40.23 mmHg (±10.74). Overall, 50.0% (95% CI: 29.9–70.1%) of IIH patients were obese, with patients 12 years of age and younger exhibiting an overall obesity rate of 30.7% and patients 13 years of age and older having an obesity rate of 69.2%. The overall allergy rate in this IIH patient population was 46.2% (95% CI: 26.6–66.6%).Conclusion: Obesity appears to have no association with IIH in younger cases, but it is a more common feature in older children. An autoimmune component may play a role in pediatric IIH, given the high rate of atopy observed in this pediatric IIH patient cohort. Because a diagnosis of IIH can have an absence of optic nerve edema, taking a detailed history and performing a thorough examination are keys to diagnosing IIH in the pediatric population.Keywords: idiopathic intracranial hypertension, papilledema, headache, obesity
format	article
author	Agraz D Morgan LA Fouzdar Jain S Suh DW
author_facet	Agraz D Morgan LA Fouzdar Jain S Suh DW
author_sort	Agraz D
title	Clinical features of pediatric idiopathic intracranial hypertension
title_short	Clinical features of pediatric idiopathic intracranial hypertension
title_full	Clinical features of pediatric idiopathic intracranial hypertension
title_fullStr	Clinical features of pediatric idiopathic intracranial hypertension
title_full_unstemmed	Clinical features of pediatric idiopathic intracranial hypertension
title_sort	clinical features of pediatric idiopathic intracranial hypertension
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/630d4e45e711496ebea3c32a4267df5f
work_keys_str_mv	AT agrazd clinicalfeaturesofpediatricidiopathicintracranialhypertension AT morganla clinicalfeaturesofpediatricidiopathicintracranialhypertension AT fouzdarjains clinicalfeaturesofpediatricidiopathicintracranialhypertension AT suhdw clinicalfeaturesofpediatricidiopathicintracranialhypertension
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Clinical features of pediatric idiopathic intracranial hypertension

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