Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma

Abstract To compare perioperative circulating tumor cells (CTC) in primary upper tract urothelial carcinoma (UTUC) patients who underwent hand-assisted retroperitoneoscopic nephroureterectomy (HANU) or robotic-assisted nephroureterectomy (RANU). A total of 29 patients received RANU (n = 10) or HANU...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hui-Kung Ting, Tai-Lung Cha, Yi-Ta Tsai, Shu-Yu Liu, Sheng-Tang Wu, En Meng, Chih-Wei Tsao, Chien-Chang Kao, Chin-Li Chen, Guang-Huan Sun, Dah-Shyong Yu, Ming-Hsin Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/630d822292744be898aafc3de5ddf06a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:630d822292744be898aafc3de5ddf06a
record_format	dspace
spelling	oai:doaj.org-article:630d822292744be898aafc3de5ddf06a2021-12-02T17:37:35ZEffects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma10.1038/s41598-021-99092-42045-2322https://doaj.org/article/630d822292744be898aafc3de5ddf06a2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99092-4https://doaj.org/toc/2045-2322Abstract To compare perioperative circulating tumor cells (CTC) in primary upper tract urothelial carcinoma (UTUC) patients who underwent hand-assisted retroperitoneoscopic nephroureterectomy (HANU) or robotic-assisted nephroureterectomy (RANU). A total of 29 patients received RANU (n = 10) or HANU (n = 19). Peripheral blood samples were collected before, 24 h after surgery (POh24) and on postoperative day 28 (POD28). The demographic and pathologic data are similar in both groups. RANU had a longer operative time (p = 0.031), less bleeding volume (p = 0.004), and comparable pain sore (p = 0.169). The mean CTC numbers before surgery (2.4 vs. 2.3, p = 0.482), POh24 (2.4 vs. 1.9, p = 0.668) and POD28 (0.5 vs. 0.6, p = 0.280) were not significant different among groups. The amount of CTCs in both groups decreased and reached similar level on POD28. No significant difference of overall and intravesical recurrence rate between the two approaches. In comparison to RANU, more surgical manipulation does not affect tumor cell translocation into the bloodstream in UTUC patients who received HANU. However, a longer follow-up would be needed for the final comparison of tumor recurrence.Hui-Kung TingTai-Lung ChaYi-Ta TsaiShu-Yu LiuSheng-Tang WuEn MengChih-Wei TsaoChien-Chang KaoChin-Li ChenGuang-Huan SunDah-Shyong YuMing-Hsin YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hui-Kung Ting Tai-Lung Cha Yi-Ta Tsai Shu-Yu Liu Sheng-Tang Wu En Meng Chih-Wei Tsao Chien-Chang Kao Chin-Li Chen Guang-Huan Sun Dah-Shyong Yu Ming-Hsin Yang Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma
description	Abstract To compare perioperative circulating tumor cells (CTC) in primary upper tract urothelial carcinoma (UTUC) patients who underwent hand-assisted retroperitoneoscopic nephroureterectomy (HANU) or robotic-assisted nephroureterectomy (RANU). A total of 29 patients received RANU (n = 10) or HANU (n = 19). Peripheral blood samples were collected before, 24 h after surgery (POh24) and on postoperative day 28 (POD28). The demographic and pathologic data are similar in both groups. RANU had a longer operative time (p = 0.031), less bleeding volume (p = 0.004), and comparable pain sore (p = 0.169). The mean CTC numbers before surgery (2.4 vs. 2.3, p = 0.482), POh24 (2.4 vs. 1.9, p = 0.668) and POD28 (0.5 vs. 0.6, p = 0.280) were not significant different among groups. The amount of CTCs in both groups decreased and reached similar level on POD28. No significant difference of overall and intravesical recurrence rate between the two approaches. In comparison to RANU, more surgical manipulation does not affect tumor cell translocation into the bloodstream in UTUC patients who received HANU. However, a longer follow-up would be needed for the final comparison of tumor recurrence.
format	article
author	Hui-Kung Ting Tai-Lung Cha Yi-Ta Tsai Shu-Yu Liu Sheng-Tang Wu En Meng Chih-Wei Tsao Chien-Chang Kao Chin-Li Chen Guang-Huan Sun Dah-Shyong Yu Ming-Hsin Yang
author_facet	Hui-Kung Ting Tai-Lung Cha Yi-Ta Tsai Shu-Yu Liu Sheng-Tang Wu En Meng Chih-Wei Tsao Chien-Chang Kao Chin-Li Chen Guang-Huan Sun Dah-Shyong Yu Ming-Hsin Yang
author_sort	Hui-Kung Ting
title	Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma
title_short	Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma
title_full	Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma
title_fullStr	Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma
title_full_unstemmed	Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma
title_sort	effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/630d822292744be898aafc3de5ddf06a
work_keys_str_mv	AT huikungting effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT tailungcha effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT yitatsai effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT shuyuliu effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT shengtangwu effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT enmeng effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT chihweitsao effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT chienchangkao effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT chinlichen effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT guanghuansun effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT dahshyongyu effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma AT minghsinyang effectsofrobotassistedversushandassistednephroureterectomyoncirculatingtumorcellsforupperurinarytracturothelialcarcinoma
_version_	1718379886739980288

Effects of robot-assisted versus hand-assisted nephroureterectomy on circulating tumor cells for upper urinary tract urothelial carcinoma

Ejemplares similares