Associated Factors in Response to Treatment in Children with Refractory Epilepsy

Associated Factors in Response to Treatment in Children with Refractory Epilepsy

BACKGROUND AND OBJECTIVE: Considering 10-20% of children with epilepsy continue to have seizure despite the appropriate treatment this study was done to determine the associated factors in response to treatment in children with refractory epilepsy attending in Mofid childrens hospital, Tehran, Iran...

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Autores principales: MM Nasehi, F Mahvalati Shamsabadi, M Ghofrani
Formato: article
Lenguaje:EN
FA
Publicado: Babol University of Medical Sciences 2010
Materias:
refractory epilepsy
children
treatment response
Medicine
R
Medicine (General)
R5-920
Acceso en línea:https://doaj.org/article/630e7b71c39d4c01b2040468823a5874
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spelling oai:doaj.org-article:630e7b71c39d4c01b2040468823a58742021-11-10T09:00:36ZAssociated Factors in Response to Treatment in Children with Refractory Epilepsy1561-41072251-7170https://doaj.org/article/630e7b71c39d4c01b2040468823a58742010-10-01T00:00:00Zhttp://jbums.org/article-1-3669-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: Considering 10-20% of children with epilepsy continue to have seizure despite the appropriate treatment this study was done to determine the associated factors in response to treatment in children with refractory epilepsy attending in Mofid childrens hospital, Tehran, Iran. METHODS: This cross-sectional study was done during one year on 150 children with refractory epilepsy in Mofid childrens hospital, Tehran, Iran. Demographic and clinical information, history, type of seizure, the number and type of drugs and treatment response were recorded by interview with parents and refer to medical recorded form. Patients who had no seizure in last year defined as a seizure free and patients who had more than 50% reduction in time or number of seizure defined as a relative response and relationship between different variables and treatment response was determined.FINDINGS: The mean age of patients was 83.5±51.14 month and 65 (43.3%) were female and 85 (56.7%) were male. Forty-nine (32.7%) had idiopathic epilepsy and 91 (57.6%) had symptomatic epilepsy. No response and relative response was seen in 74 (49.3%) and 20 (13.3%) respectively and 56 (37.3%) was seizure free. Response to treatment had significant difference between idiopathic epilepsy and symptomatic epilepsy (p=0.049). There was not significant difference between response to treatment with sex, family relation of parents, history of neonatal asphyxia and icter, preterm labor and microcephaly, gestational age, muscle tonicity, early age of onset and family history of seizure.CONCLUSION: Results show that symptomatic seizure had significant effect on response to treatment and these patients had worst response to antiepileptic drugs.MM NasehiF Mahvalati ShamsabadiM GhofraniBabol University of Medical Sciencesarticlerefractory epilepsychildrentreatment responseMedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 12, Iss 4, Pp 61-66 (2010)
institution DOAJ
collection DOAJ
language EN
FA
topic refractory epilepsy
children
treatment response
Medicine
R
Medicine (General)
R5-920
spellingShingle refractory epilepsy
children
treatment response
Medicine
R
Medicine (General)
R5-920
MM Nasehi
F Mahvalati Shamsabadi
M Ghofrani
Associated Factors in Response to Treatment in Children with Refractory Epilepsy
description BACKGROUND AND OBJECTIVE: Considering 10-20% of children with epilepsy continue to have seizure despite the appropriate treatment this study was done to determine the associated factors in response to treatment in children with refractory epilepsy attending in Mofid childrens hospital, Tehran, Iran. METHODS: This cross-sectional study was done during one year on 150 children with refractory epilepsy in Mofid childrens hospital, Tehran, Iran. Demographic and clinical information, history, type of seizure, the number and type of drugs and treatment response were recorded by interview with parents and refer to medical recorded form. Patients who had no seizure in last year defined as a seizure free and patients who had more than 50% reduction in time or number of seizure defined as a relative response and relationship between different variables and treatment response was determined.FINDINGS: The mean age of patients was 83.5±51.14 month and 65 (43.3%) were female and 85 (56.7%) were male. Forty-nine (32.7%) had idiopathic epilepsy and 91 (57.6%) had symptomatic epilepsy. No response and relative response was seen in 74 (49.3%) and 20 (13.3%) respectively and 56 (37.3%) was seizure free. Response to treatment had significant difference between idiopathic epilepsy and symptomatic epilepsy (p=0.049). There was not significant difference between response to treatment with sex, family relation of parents, history of neonatal asphyxia and icter, preterm labor and microcephaly, gestational age, muscle tonicity, early age of onset and family history of seizure.CONCLUSION: Results show that symptomatic seizure had significant effect on response to treatment and these patients had worst response to antiepileptic drugs.
format article
author MM Nasehi
F Mahvalati Shamsabadi
M Ghofrani
author_facet MM Nasehi
F Mahvalati Shamsabadi
M Ghofrani
author_sort MM Nasehi
title Associated Factors in Response to Treatment in Children with Refractory Epilepsy
title_short Associated Factors in Response to Treatment in Children with Refractory Epilepsy
title_full Associated Factors in Response to Treatment in Children with Refractory Epilepsy
title_fullStr Associated Factors in Response to Treatment in Children with Refractory Epilepsy
title_full_unstemmed Associated Factors in Response to Treatment in Children with Refractory Epilepsy
title_sort associated factors in response to treatment in children with refractory epilepsy
publisher Babol University of Medical Sciences
publishDate 2010
url https://doaj.org/article/630e7b71c39d4c01b2040468823a5874
work_keys_str_mv AT mmnasehi associatedfactorsinresponsetotreatmentinchildrenwithrefractoryepilepsy
AT fmahvalatishamsabadi associatedfactorsinresponsetotreatmentinchildrenwithrefractoryepilepsy
AT mghofrani associatedfactorsinresponsetotreatmentinchildrenwithrefractoryepilepsy
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