Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

Immune cells are shaped by the tissue environment, yet the states of healthy human T cells are mainly studied in the blood. Here, the authors perform single cell RNA-seq of T cells from tissues and blood of healthy donors and show its utility as a reference map for comparison of human T cell states...

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Autores principales:	Peter A. Szabo, Hanna Mendes Levitin, Michelle Miron, Mark E. Snyder, Takashi Senda, Jinzhou Yuan, Yim Ling Cheng, Erin C. Bush, Pranay Dogra, Puspa Thapa, Donna L. Farber, Peter A. Sims
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/630f23689fa444fe9d811c61653d4606
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spelling	oai:doaj.org-article:630f23689fa444fe9d811c61653d46062021-12-02T15:35:10ZSingle-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease10.1038/s41467-019-12464-32041-1723https://doaj.org/article/630f23689fa444fe9d811c61653d46062019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12464-3https://doaj.org/toc/2041-1723Immune cells are shaped by the tissue environment, yet the states of healthy human T cells are mainly studied in the blood. Here, the authors perform single cell RNA-seq of T cells from tissues and blood of healthy donors and show its utility as a reference map for comparison of human T cell states in disease.Peter A. SzaboHanna Mendes LevitinMichelle MironMark E. SnyderTakashi SendaJinzhou YuanYim Ling ChengErin C. BushPranay DograPuspa ThapaDonna L. FarberPeter A. SimsNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Peter A. Szabo Hanna Mendes Levitin Michelle Miron Mark E. Snyder Takashi Senda Jinzhou Yuan Yim Ling Cheng Erin C. Bush Pranay Dogra Puspa Thapa Donna L. Farber Peter A. Sims Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
description	Immune cells are shaped by the tissue environment, yet the states of healthy human T cells are mainly studied in the blood. Here, the authors perform single cell RNA-seq of T cells from tissues and blood of healthy donors and show its utility as a reference map for comparison of human T cell states in disease.
format	article
author	Peter A. Szabo Hanna Mendes Levitin Michelle Miron Mark E. Snyder Takashi Senda Jinzhou Yuan Yim Ling Cheng Erin C. Bush Pranay Dogra Puspa Thapa Donna L. Farber Peter A. Sims
author_facet	Peter A. Szabo Hanna Mendes Levitin Michelle Miron Mark E. Snyder Takashi Senda Jinzhou Yuan Yim Ling Cheng Erin C. Bush Pranay Dogra Puspa Thapa Donna L. Farber Peter A. Sims
author_sort	Peter A. Szabo
title	Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
title_short	Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
title_full	Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
title_fullStr	Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
title_full_unstemmed	Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease
title_sort	single-cell transcriptomics of human t cells reveals tissue and activation signatures in health and disease
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/630f23689fa444fe9d811c61653d4606
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Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease

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