P113 is a merozoite surface protein that binds the N terminus of Plasmodium falciparum RH5

The secretedPlasmodium falciparum protein RH5 is essential for invasion of erythrocytes and is a promising vaccine candidate. Here, Galaway et al. show that the N-terminal region of RH5 binds the GPI-anchored merozoite surface protein P113 and can elicit invasion-blocking antibodies.

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Detalles Bibliográficos
Autores principales: Francis Galaway, Laura G. Drought, Maria Fala, Nadia Cross, Alison C. Kemp, Julian C. Rayner, Gavin J. Wright
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/63120ffd24804c9eb22499b33bf94e28
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Sumario:The secretedPlasmodium falciparum protein RH5 is essential for invasion of erythrocytes and is a promising vaccine candidate. Here, Galaway et al. show that the N-terminal region of RH5 binds the GPI-anchored merozoite surface protein P113 and can elicit invasion-blocking antibodies.