Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes

Novel GPR120 Agonists with Improved Pharmacokinetic Profiles for the Treatment of Type 2 Diabetes

GPR120 is a promising target for the treatment of type 2 diabetes (T2DM), which is activated by free fatty acids (FFAs) and stimulates the release of glucagon-like peptide-1(GLP-1). GLP-1, as an incretin, can enhance glucose-dependent secretion of insulin from pancreatic beta cells and reduce blood...

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Bibliographic Details
Main Authors: Guoxia Ji, Qinghua Guo, Qidi Xue, Ruifang Kong, Shiben Wang, Kang Lei, Renmin Liu, Xuekun Wang
Format: article
Language:EN
Published: MDPI AG 2021
Subjects:
GPR120
synthesis
type 2 diabetes
pharmacokinetic profiles
Organic chemistry
QD241-441
Online Access:https://doaj.org/article/63131e8f92c846e99c5f3dfc66a20761
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https://doaj.org/article/63131e8f92c846e99c5f3dfc66a20761

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