Low-affinity CD4+ T cells are major responders in the primary immune response

MHC II tetramers are used to study T cell expansion but they preferentially bind high affinity T cell receptors. Here the authors show that T cells with low affinity receptors expand in number along with the T-cell repertoire and might therefore contribute more to the primary immune response than wa...

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Autores principales:	Ryan J. Martinez, Rakieb Andargachew, Hunter A. Martinez, Brian D. Evavold
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6313a9aa2c214c3d8e93fd17d0443014
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spelling	oai:doaj.org-article:6313a9aa2c214c3d8e93fd17d04430142021-12-02T17:33:10ZLow-affinity CD4+ T cells are major responders in the primary immune response10.1038/ncomms138482041-1723https://doaj.org/article/6313a9aa2c214c3d8e93fd17d04430142016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13848https://doaj.org/toc/2041-1723MHC II tetramers are used to study T cell expansion but they preferentially bind high affinity T cell receptors. Here the authors show that T cells with low affinity receptors expand in number along with the T-cell repertoire and might therefore contribute more to the primary immune response than was thought.Ryan J. MartinezRakieb AndargachewHunter A. MartinezBrian D. EvavoldNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryan J. Martinez Rakieb Andargachew Hunter A. Martinez Brian D. Evavold Low-affinity CD4+ T cells are major responders in the primary immune response
description	MHC II tetramers are used to study T cell expansion but they preferentially bind high affinity T cell receptors. Here the authors show that T cells with low affinity receptors expand in number along with the T-cell repertoire and might therefore contribute more to the primary immune response than was thought.
format	article
author	Ryan J. Martinez Rakieb Andargachew Hunter A. Martinez Brian D. Evavold
author_facet	Ryan J. Martinez Rakieb Andargachew Hunter A. Martinez Brian D. Evavold
author_sort	Ryan J. Martinez
title	Low-affinity CD4+ T cells are major responders in the primary immune response
title_short	Low-affinity CD4+ T cells are major responders in the primary immune response
title_full	Low-affinity CD4+ T cells are major responders in the primary immune response
title_fullStr	Low-affinity CD4+ T cells are major responders in the primary immune response
title_full_unstemmed	Low-affinity CD4+ T cells are major responders in the primary immune response
title_sort	low-affinity cd4+ t cells are major responders in the primary immune response
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6313a9aa2c214c3d8e93fd17d0443014
work_keys_str_mv	AT ryanjmartinez lowaffinitycd4tcellsaremajorrespondersintheprimaryimmuneresponse AT rakiebandargachew lowaffinitycd4tcellsaremajorrespondersintheprimaryimmuneresponse AT hunteramartinez lowaffinitycd4tcellsaremajorrespondersintheprimaryimmuneresponse AT briandevavold lowaffinitycd4tcellsaremajorrespondersintheprimaryimmuneresponse
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Low-affinity CD4+ T cells are major responders in the primary immune response

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