Low-affinity CD4+ T cells are major responders in the primary immune response

MHC II tetramers are used to study T cell expansion but they preferentially bind high affinity T cell receptors. Here the authors show that T cells with low affinity receptors expand in number along with the T-cell repertoire and might therefore contribute more to the primary immune response than wa...

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Autores principales: Ryan J. Martinez, Rakieb Andargachew, Hunter A. Martinez, Brian D. Evavold
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/6313a9aa2c214c3d8e93fd17d0443014
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