Immunogenetics of new onset diabetes after transplantation in Kuwait

Mohamed Jahromi,1 Torki Al-Otaibi,2 Nashwa Othman,3 Osama Gheith,2 Tarek Mahmoud,2 Prasad Nair,2 Medhat A Halim,2 Narayanam Nampoory1,21Clinical Research, Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait; 2Nephrology Department, Hamid Al-Essa Organ Transplant Center, Kuwait City, Kuw...

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Autores principales:	Jahromi M, Al-Otaibi T, Othman N, Gheith O, Mahmoud T, Nair P, Halim MA, Nampoory N
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	ethnicity NODAT transplantation immunosuppression Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/631a534fcfea4f55bfded280e6e3da9a
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spelling	oai:doaj.org-article:631a534fcfea4f55bfded280e6e3da9a2021-12-02T07:32:35ZImmunogenetics of new onset diabetes after transplantation in Kuwait1178-7007https://doaj.org/article/631a534fcfea4f55bfded280e6e3da9a2019-05-01T00:00:00Zhttps://www.dovepress.com/immunogenetics-of-new-onset-diabetes-after-transplantation-in-kuwait-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Mohamed Jahromi,1 Torki Al-Otaibi,2 Nashwa Othman,3 Osama Gheith,2 Tarek Mahmoud,2 Prasad Nair,2 Medhat A Halim,2 Narayanam Nampoory1,21Clinical Research, Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait; 2Nephrology Department, Hamid Al-Essa Organ Transplant Center, Kuwait City, Kuwait; 3Education, Clinical Services Division, Dasman Diabetes Institute, Kuwait City, KuwaitIntroduction and aim: New onset diabetes after transplantation (NODAT) is a serious metabolic complication following kidney transplantation. Although beta-cell dysfunction is considered the main contributing factor in the development of this complication, its exact etiology is yet to be identified. We aimed to investigate NODAT among kidney transplant cohort in Kuwait with special stress on correlation between its risk factors and interferon gamma genotyping.Materials and methods: We surveyed 309 kidney transplant recipients from Hamed Al Essa Transplantation Centre, Kuwait. The participants were categorized into cohorts according to the development of NODAT diagnosed based on the American Diabetes Association guidelines. Statistical analyses were performed using SPSS software. We genotyped interferon gamma as the leading immunosignature for T lymphocyte.Results: No relationship between ethnicity and the development of NODAT was identified. However, there was a significant difference in age between cohorts. Younger patients demonstrated a lower rate of NODAT while, NODAT reached its maximum in 40–60-year age group. IFNG TT genotype was significantly associated with NODAT (p=0.005), while IFNG AA was considerably higher in the non-NODAT group.Conclusion: Beside the conventional contributing factors of NODAT, our results might represent a suitable platform for a larger cytokine and chemokine spectrum genotyping.Keywords: ethnicity, NODAT, transplantation, immunosuppressionJahromi MAl-Otaibi TOthman NGheith OMahmoud TNair PHalim MANampoory NDove Medical PressarticleethnicityNODATtransplantationimmunosuppressionSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 12, Pp 731-742 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	ethnicity NODAT transplantation immunosuppression Specialties of internal medicine RC581-951
spellingShingle	ethnicity NODAT transplantation immunosuppression Specialties of internal medicine RC581-951 Jahromi M Al-Otaibi T Othman N Gheith O Mahmoud T Nair P Halim MA Nampoory N Immunogenetics of new onset diabetes after transplantation in Kuwait
description	Mohamed Jahromi,1 Torki Al-Otaibi,2 Nashwa Othman,3 Osama Gheith,2 Tarek Mahmoud,2 Prasad Nair,2 Medhat A Halim,2 Narayanam Nampoory1,21Clinical Research, Medical Division, Dasman Diabetes Institute, Kuwait City, Kuwait; 2Nephrology Department, Hamid Al-Essa Organ Transplant Center, Kuwait City, Kuwait; 3Education, Clinical Services Division, Dasman Diabetes Institute, Kuwait City, KuwaitIntroduction and aim: New onset diabetes after transplantation (NODAT) is a serious metabolic complication following kidney transplantation. Although beta-cell dysfunction is considered the main contributing factor in the development of this complication, its exact etiology is yet to be identified. We aimed to investigate NODAT among kidney transplant cohort in Kuwait with special stress on correlation between its risk factors and interferon gamma genotyping.Materials and methods: We surveyed 309 kidney transplant recipients from Hamed Al Essa Transplantation Centre, Kuwait. The participants were categorized into cohorts according to the development of NODAT diagnosed based on the American Diabetes Association guidelines. Statistical analyses were performed using SPSS software. We genotyped interferon gamma as the leading immunosignature for T lymphocyte.Results: No relationship between ethnicity and the development of NODAT was identified. However, there was a significant difference in age between cohorts. Younger patients demonstrated a lower rate of NODAT while, NODAT reached its maximum in 40–60-year age group. IFNG TT genotype was significantly associated with NODAT (p=0.005), while IFNG AA was considerably higher in the non-NODAT group.Conclusion: Beside the conventional contributing factors of NODAT, our results might represent a suitable platform for a larger cytokine and chemokine spectrum genotyping.Keywords: ethnicity, NODAT, transplantation, immunosuppression
format	article
author	Jahromi M Al-Otaibi T Othman N Gheith O Mahmoud T Nair P Halim MA Nampoory N
author_facet	Jahromi M Al-Otaibi T Othman N Gheith O Mahmoud T Nair P Halim MA Nampoory N
author_sort	Jahromi M
title	Immunogenetics of new onset diabetes after transplantation in Kuwait
title_short	Immunogenetics of new onset diabetes after transplantation in Kuwait
title_full	Immunogenetics of new onset diabetes after transplantation in Kuwait
title_fullStr	Immunogenetics of new onset diabetes after transplantation in Kuwait
title_full_unstemmed	Immunogenetics of new onset diabetes after transplantation in Kuwait
title_sort	immunogenetics of new onset diabetes after transplantation in kuwait
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/631a534fcfea4f55bfded280e6e3da9a
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_version_	1718399339432247296

Immunogenetics of new onset diabetes after transplantation in Kuwait

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