Alternative splicing acts as an independent prognosticator in ovarian carcinoma

Abstract Alternative splicing (AS) events associated with oncogenic processes present anomalous perturbations in many cancers, including ovarian carcinoma. There are no reliable features to predict survival outcomes for ovarian cancer patients. In this study, comprehensive profiling of AS events was...

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Autores principales:	Yan Ouyang, Kaide Xia, Xue Yang, Shichao Zhang, Li Wang, Shan Ren, Houming Zhou, Yi Liu, Fuzhou Tang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/631d090fcb1a4353b0f5eebd5978b5ab
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spelling	oai:doaj.org-article:631d090fcb1a4353b0f5eebd5978b5ab2021-12-02T14:59:09ZAlternative splicing acts as an independent prognosticator in ovarian carcinoma10.1038/s41598-021-89778-02045-2322https://doaj.org/article/631d090fcb1a4353b0f5eebd5978b5ab2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89778-0https://doaj.org/toc/2045-2322Abstract Alternative splicing (AS) events associated with oncogenic processes present anomalous perturbations in many cancers, including ovarian carcinoma. There are no reliable features to predict survival outcomes for ovarian cancer patients. In this study, comprehensive profiling of AS events was conducted by integrating AS data and clinical information of ovarian serous cystadenocarcinoma (OV). Survival-related AS events were identified by Univariate Cox regression analysis. Then, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis were used to construct the prognostic signatures within each AS type. Furthermore, we established a splicing-related network to reveal the potential regulatory mechanisms between splicing factors and candidate AS events. A total of 730 AS events were identified as survival-associated splicing events, and the final prognostic signature based on all seven types of AS events could serve as an independent prognostic indicator and had powerful efficiency in distinguishing patient outcomes. In addition, survival-related AS events might be involved in tumor-related pathways including base excision repair and pyrimidine metabolism pathways, and some splicing factors might be correlated with prognosis-related AS events, including SPEN, SF3B5, RNPC3, LUC7L3, SRSF11 and PRPF38B. Our study constructs an independent prognostic signature for predicting ovarian cancer patients’ survival outcome and contributes to elucidating the underlying mechanism of AS in tumor development.Yan OuyangKaide XiaXue YangShichao ZhangLi WangShan RenHouming ZhouYi LiuFuzhou TangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yan Ouyang Kaide Xia Xue Yang Shichao Zhang Li Wang Shan Ren Houming Zhou Yi Liu Fuzhou Tang Alternative splicing acts as an independent prognosticator in ovarian carcinoma
description	Abstract Alternative splicing (AS) events associated with oncogenic processes present anomalous perturbations in many cancers, including ovarian carcinoma. There are no reliable features to predict survival outcomes for ovarian cancer patients. In this study, comprehensive profiling of AS events was conducted by integrating AS data and clinical information of ovarian serous cystadenocarcinoma (OV). Survival-related AS events were identified by Univariate Cox regression analysis. Then, least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression analysis were used to construct the prognostic signatures within each AS type. Furthermore, we established a splicing-related network to reveal the potential regulatory mechanisms between splicing factors and candidate AS events. A total of 730 AS events were identified as survival-associated splicing events, and the final prognostic signature based on all seven types of AS events could serve as an independent prognostic indicator and had powerful efficiency in distinguishing patient outcomes. In addition, survival-related AS events might be involved in tumor-related pathways including base excision repair and pyrimidine metabolism pathways, and some splicing factors might be correlated with prognosis-related AS events, including SPEN, SF3B5, RNPC3, LUC7L3, SRSF11 and PRPF38B. Our study constructs an independent prognostic signature for predicting ovarian cancer patients’ survival outcome and contributes to elucidating the underlying mechanism of AS in tumor development.
format	article
author	Yan Ouyang Kaide Xia Xue Yang Shichao Zhang Li Wang Shan Ren Houming Zhou Yi Liu Fuzhou Tang
author_facet	Yan Ouyang Kaide Xia Xue Yang Shichao Zhang Li Wang Shan Ren Houming Zhou Yi Liu Fuzhou Tang
author_sort	Yan Ouyang
title	Alternative splicing acts as an independent prognosticator in ovarian carcinoma
title_short	Alternative splicing acts as an independent prognosticator in ovarian carcinoma
title_full	Alternative splicing acts as an independent prognosticator in ovarian carcinoma
title_fullStr	Alternative splicing acts as an independent prognosticator in ovarian carcinoma
title_full_unstemmed	Alternative splicing acts as an independent prognosticator in ovarian carcinoma
title_sort	alternative splicing acts as an independent prognosticator in ovarian carcinoma
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/631d090fcb1a4353b0f5eebd5978b5ab
work_keys_str_mv	AT yanouyang alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT kaidexia alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT xueyang alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT shichaozhang alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT liwang alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT shanren alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT houmingzhou alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT yiliu alternativesplicingactsasanindependentprognosticatorinovariancarcinoma AT fuzhoutang alternativesplicingactsasanindependentprognosticatorinovariancarcinoma
_version_	1718389204048674816

Alternative splicing acts as an independent prognosticator in ovarian carcinoma

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