PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

Arginine methylation has been reported to regulate AKT-associated signalling. Here, the authors show that PRMT5-mediated arginine methylation promotes AKT activity and induces tumourigenesis.

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Autores principales:	Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E. Ball, Shaun K. Olsen, Michael C. Ostrowski, Wenjian Gan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/631d7841dc4149218d5fce9d5cee9748
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spelling	oai:doaj.org-article:631d7841dc4149218d5fce9d5cee97482021-12-02T15:02:50ZPRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis10.1038/s41467-021-23833-22041-1723https://doaj.org/article/631d7841dc4149218d5fce9d5cee97482021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23833-2https://doaj.org/toc/2041-1723Arginine methylation has been reported to regulate AKT-associated signalling. Here, the authors show that PRMT5-mediated arginine methylation promotes AKT activity and induces tumourigenesis.Shasha YinLiu LiuCharles BrobbeyViswanathan PalanisamyLauren E. BallShaun K. OlsenMichael C. OstrowskiWenjian GanNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shasha Yin Liu Liu Charles Brobbey Viswanathan Palanisamy Lauren E. Ball Shaun K. Olsen Michael C. Ostrowski Wenjian Gan PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
description	Arginine methylation has been reported to regulate AKT-associated signalling. Here, the authors show that PRMT5-mediated arginine methylation promotes AKT activity and induces tumourigenesis.
format	article
author	Shasha Yin Liu Liu Charles Brobbey Viswanathan Palanisamy Lauren E. Ball Shaun K. Olsen Michael C. Ostrowski Wenjian Gan
author_facet	Shasha Yin Liu Liu Charles Brobbey Viswanathan Palanisamy Lauren E. Ball Shaun K. Olsen Michael C. Ostrowski Wenjian Gan
author_sort	Shasha Yin
title	PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
title_short	PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
title_full	PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
title_fullStr	PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
title_full_unstemmed	PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis
title_sort	prmt5-mediated arginine methylation activates akt kinase to govern tumorigenesis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/631d7841dc4149218d5fce9d5cee9748
work_keys_str_mv	AT shashayin prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis AT liuliu prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis AT charlesbrobbey prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis AT viswanathanpalanisamy prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis AT laureneball prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis AT shaunkolsen prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis AT michaelcostrowski prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis AT wenjiangan prmt5mediatedargininemethylationactivatesaktkinasetogoverntumorigenesis
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PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis

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