piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair

Mallick et al. investigate the role of the piRNA, piR-39980, and doxorubicin (DOX) resistance in fibrosarcoma, finding that piR-39980 is less expressed in DOX-resistant HT1080 fibrosarcoma cells. The authors reported that its inhibition lead to attenuated intracellular DOX accumulation, DOX-indued a...

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Autores principales:	Basudeb Das, Neha Jain, Bibekanand Mallick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/631ec95798a34a43b3ccb13e844cbae0
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spelling	oai:doaj.org-article:631ec95798a34a43b3ccb13e844cbae02021-11-21T12:08:22ZpiR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair10.1038/s42003-021-02844-12399-3642https://doaj.org/article/631ec95798a34a43b3ccb13e844cbae02021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02844-1https://doaj.org/toc/2399-3642Mallick et al. investigate the role of the piRNA, piR-39980, and doxorubicin (DOX) resistance in fibrosarcoma, finding that piR-39980 is less expressed in DOX-resistant HT1080 fibrosarcoma cells. The authors reported that its inhibition lead to attenuated intracellular DOX accumulation, DOX-indued apoptosis and anti-proliferative effects in parental HT1080 cells, as well as DNA damage by regulating RRM2 and CYP1A2.Basudeb DasNeha JainBibekanand MallickNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Basudeb Das Neha Jain Bibekanand Mallick piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair
description	Mallick et al. investigate the role of the piRNA, piR-39980, and doxorubicin (DOX) resistance in fibrosarcoma, finding that piR-39980 is less expressed in DOX-resistant HT1080 fibrosarcoma cells. The authors reported that its inhibition lead to attenuated intracellular DOX accumulation, DOX-indued apoptosis and anti-proliferative effects in parental HT1080 cells, as well as DNA damage by regulating RRM2 and CYP1A2.
format	article
author	Basudeb Das Neha Jain Bibekanand Mallick
author_facet	Basudeb Das Neha Jain Bibekanand Mallick
author_sort	Basudeb Das
title	piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair
title_short	piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair
title_full	piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair
title_fullStr	piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair
title_full_unstemmed	piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair
title_sort	pir-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and dna repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/631ec95798a34a43b3ccb13e844cbae0
work_keys_str_mv	AT basudebdas pir39980mediatesdoxorubicinresistanceinfibrosarcomabyregulatingdrugaccumulationanddnarepair AT nehajain pir39980mediatesdoxorubicinresistanceinfibrosarcomabyregulatingdrugaccumulationanddnarepair AT bibekanandmallick pir39980mediatesdoxorubicinresistanceinfibrosarcomabyregulatingdrugaccumulationanddnarepair
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piR-39980 mediates doxorubicin resistance in fibrosarcoma by regulating drug accumulation and DNA repair

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