Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization

Abstract Demineralization of hard tooth tissues leads to dental caries, which cause health problems and economic burdens throughout the world. A biomimetic mineralization strategy is expected to reverse early dental caries. Commercially available anti-carious mineralizing products lead to inconclusi...

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Autores principales:	Zhe Wang, Zihuai Zhou, Jiayan Fan, Leiqing Zhang, Zhixin Zhang, Zhifang Wu, Ying Shi, Haiyan Zheng, Zhengyi Zhang, Ruikang Tang, Baiping Fu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Dental caries Hydroxypropylmethylcellulose Film Biomimetic mineralization Dentin Collagen Biotechnology TP248.13-248.65 Medical technology R855-855.5
Acceso en línea:	https://doaj.org/article/631f90aec852433da23877f001a35c70
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spelling	oai:doaj.org-article:631f90aec852433da23877f001a35c702021-11-28T12:26:31ZHydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization10.1186/s12951-021-01133-71477-3155https://doaj.org/article/631f90aec852433da23877f001a35c702021-11-01T00:00:00Zhttps://doi.org/10.1186/s12951-021-01133-7https://doaj.org/toc/1477-3155Abstract Demineralization of hard tooth tissues leads to dental caries, which cause health problems and economic burdens throughout the world. A biomimetic mineralization strategy is expected to reverse early dental caries. Commercially available anti-carious mineralizing products lead to inconclusive clinical results because they cannot continuously replenish the required calcium and phosphate resources. Herein, we prepared a mineralizing film consisting of hydroxypropylmethylcellulose (HPMC) and polyaspartic acid-stabilized amorphous calcium phosphate (PAsp-ACP) nanoparticles. HPMC which contains multiple hydroxyl groups is a film-forming material that can be desiccated to form a dry film. In a moist environment, this film gradually changes into a gel. HPMC was used as the carrier of PAsp-ACP nanoparticles to deliver biomimetic mineralization. Our results indicated that the hydroxyl and methoxyl groups of HPMC could assist the stability of PAsp-ACP nanoparticles and maintain their biomimetic mineralization activity. The results further demonstrated that the bioinspired mineralizing film induced the early mineralization of demineralized dentin after 24 h with increasing mineralization of the whole demineralized dentin (3–4 µm) after 72–96 h. Furthermore, these results were achieved without any cytotoxicity or mucosa irritation. Therefore, this mineralizing film shows promise for use in preventive dentistry due to its efficient mineralization capability. Graphical AbstractZhe WangZihuai ZhouJiayan FanLeiqing ZhangZhixin ZhangZhifang WuYing ShiHaiyan ZhengZhengyi ZhangRuikang TangBaiping FuBMCarticleDental cariesHydroxypropylmethylcelluloseFilmBiomimetic mineralizationDentinCollagenBiotechnologyTP248.13-248.65Medical technologyR855-855.5ENJournal of Nanobiotechnology, Vol 19, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dental caries Hydroxypropylmethylcellulose Film Biomimetic mineralization Dentin Collagen Biotechnology TP248.13-248.65 Medical technology R855-855.5
spellingShingle	Dental caries Hydroxypropylmethylcellulose Film Biomimetic mineralization Dentin Collagen Biotechnology TP248.13-248.65 Medical technology R855-855.5 Zhe Wang Zihuai Zhou Jiayan Fan Leiqing Zhang Zhixin Zhang Zhifang Wu Ying Shi Haiyan Zheng Zhengyi Zhang Ruikang Tang Baiping Fu Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization
description	Abstract Demineralization of hard tooth tissues leads to dental caries, which cause health problems and economic burdens throughout the world. A biomimetic mineralization strategy is expected to reverse early dental caries. Commercially available anti-carious mineralizing products lead to inconclusive clinical results because they cannot continuously replenish the required calcium and phosphate resources. Herein, we prepared a mineralizing film consisting of hydroxypropylmethylcellulose (HPMC) and polyaspartic acid-stabilized amorphous calcium phosphate (PAsp-ACP) nanoparticles. HPMC which contains multiple hydroxyl groups is a film-forming material that can be desiccated to form a dry film. In a moist environment, this film gradually changes into a gel. HPMC was used as the carrier of PAsp-ACP nanoparticles to deliver biomimetic mineralization. Our results indicated that the hydroxyl and methoxyl groups of HPMC could assist the stability of PAsp-ACP nanoparticles and maintain their biomimetic mineralization activity. The results further demonstrated that the bioinspired mineralizing film induced the early mineralization of demineralized dentin after 24 h with increasing mineralization of the whole demineralized dentin (3–4 µm) after 72–96 h. Furthermore, these results were achieved without any cytotoxicity or mucosa irritation. Therefore, this mineralizing film shows promise for use in preventive dentistry due to its efficient mineralization capability. Graphical Abstract
format	article
author	Zhe Wang Zihuai Zhou Jiayan Fan Leiqing Zhang Zhixin Zhang Zhifang Wu Ying Shi Haiyan Zheng Zhengyi Zhang Ruikang Tang Baiping Fu
author_facet	Zhe Wang Zihuai Zhou Jiayan Fan Leiqing Zhang Zhixin Zhang Zhifang Wu Ying Shi Haiyan Zheng Zhengyi Zhang Ruikang Tang Baiping Fu
author_sort	Zhe Wang
title	Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization
title_short	Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization
title_full	Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization
title_fullStr	Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization
title_full_unstemmed	Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization
title_sort	hydroxypropylmethylcellulose as a film and hydrogel carrier for acp nanoprecursors to deliver biomimetic mineralization
publisher	BMC
publishDate	2021
url	https://doaj.org/article/631f90aec852433da23877f001a35c70
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Hydroxypropylmethylcellulose as a film and hydrogel carrier for ACP nanoprecursors to deliver biomimetic mineralization

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