Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

Chromosome instability can be caused by replication stress, although the mechanism is unclear. Here, the authors show that inducing mild replication stress in cancerous and non-cancerous cell lines leads to centriole disengagement and the subsequent formation of lagging chromosomes and micronuclei.

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Autores principales:	Therese Wilhelm, Anna-Maria Olziersky, Daniela Harry, Filipe De Sousa, Helène Vassal, Anja Eskat, Patrick Meraldi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6322433921614694927a36400c6241d9
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spelling	oai:doaj.org-article:6322433921614694927a36400c6241d92021-12-02T15:35:40ZMild replication stress causes chromosome mis-segregation via premature centriole disengagement10.1038/s41467-019-11584-02041-1723https://doaj.org/article/6322433921614694927a36400c6241d92019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11584-0https://doaj.org/toc/2041-1723Chromosome instability can be caused by replication stress, although the mechanism is unclear. Here, the authors show that inducing mild replication stress in cancerous and non-cancerous cell lines leads to centriole disengagement and the subsequent formation of lagging chromosomes and micronuclei.Therese WilhelmAnna-Maria OlzierskyDaniela HarryFilipe De SousaHelène VassalAnja EskatPatrick MeraldiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Therese Wilhelm Anna-Maria Olziersky Daniela Harry Filipe De Sousa Helène Vassal Anja Eskat Patrick Meraldi Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
description	Chromosome instability can be caused by replication stress, although the mechanism is unclear. Here, the authors show that inducing mild replication stress in cancerous and non-cancerous cell lines leads to centriole disengagement and the subsequent formation of lagging chromosomes and micronuclei.
format	article
author	Therese Wilhelm Anna-Maria Olziersky Daniela Harry Filipe De Sousa Helène Vassal Anja Eskat Patrick Meraldi
author_facet	Therese Wilhelm Anna-Maria Olziersky Daniela Harry Filipe De Sousa Helène Vassal Anja Eskat Patrick Meraldi
author_sort	Therese Wilhelm
title	Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
title_short	Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
title_full	Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
title_fullStr	Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
title_full_unstemmed	Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
title_sort	mild replication stress causes chromosome mis-segregation via premature centriole disengagement
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/6322433921614694927a36400c6241d9
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Mild replication stress causes chromosome mis-segregation via premature centriole disengagement

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