Systemic adverse events after screening of retinopathy of prematurity with mydriatic.

<h4>Purpose</h4>To evaluate systemic adverse events after screening for retinopathy of prematurity (ROP) performed with mydriatic.<h4>Methods</h4>This was a retrospective case series study. Medical records of consecutive patients who underwent screening for ROP with 0.5% phen...

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Autores principales: Shumpei Obata, Taku Imamura, Masashi Kakinoki, Takahide Yanagi, Yoshihiro Maruo, Masahito Ohji
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Publicado: Public Library of Science (PLoS) 2021
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spelling oai:doaj.org-article:63249ec9cc314c6399bf23de97ee17a62021-12-02T20:08:23ZSystemic adverse events after screening of retinopathy of prematurity with mydriatic.1932-620310.1371/journal.pone.0256878https://doaj.org/article/63249ec9cc314c6399bf23de97ee17a62021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0256878https://doaj.org/toc/1932-6203<h4>Purpose</h4>To evaluate systemic adverse events after screening for retinopathy of prematurity (ROP) performed with mydriatic.<h4>Methods</h4>This was a retrospective case series study. Medical records of consecutive patients who underwent screening for ROP with 0.5% phenylephrine and 0.5% tropicamide eyedrops were retrospectively reviewed. The score of abdominal distention (0-5), volume of milk sucked and volume of stool, along with systemic details (pulse and respiration rates, blood pressure and number of periods of apnea) were collected at 1 week and 1 day before ROP examination, and at 1 day after examination. Results were compared between the days before and after examination. Correlation between body weight at the time of examination and the score of abdominal distention was examined. The numbers of infants with abdominal and/or systemic adverse events were compared between pre- and post-examination periods.<h4>Results</h4>Eighty-six infants met the inclusion criteria. The score of abdominal distention increased from 2.0 at 1 day before examination to 2.3 at 1 day after examination (p = 0.005), and the number of infants who had worsened abdominal distension increased after examination (p = 0.01). Infants with lower body weight had a higher score of abdominal distention (p < 0.0001, r = -0.57). The number of infants with reduced milk consumption increased after examination (p = 0.0001), as did the number of infants with decreased pulse rate (p = 0.0008).<h4>Conclusions</h4>Screening for ROP with mydriatic may have adverse effects on systemic conditions. Infants should be carefully monitored after ROP screening with mydriatic.Shumpei ObataTaku ImamuraMasashi KakinokiTakahide YanagiYoshihiro MaruoMasahito OhjiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 9, p e0256878 (2021)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Shumpei Obata
Taku Imamura
Masashi Kakinoki
Takahide Yanagi
Yoshihiro Maruo
Masahito Ohji
Systemic adverse events after screening of retinopathy of prematurity with mydriatic.
description <h4>Purpose</h4>To evaluate systemic adverse events after screening for retinopathy of prematurity (ROP) performed with mydriatic.<h4>Methods</h4>This was a retrospective case series study. Medical records of consecutive patients who underwent screening for ROP with 0.5% phenylephrine and 0.5% tropicamide eyedrops were retrospectively reviewed. The score of abdominal distention (0-5), volume of milk sucked and volume of stool, along with systemic details (pulse and respiration rates, blood pressure and number of periods of apnea) were collected at 1 week and 1 day before ROP examination, and at 1 day after examination. Results were compared between the days before and after examination. Correlation between body weight at the time of examination and the score of abdominal distention was examined. The numbers of infants with abdominal and/or systemic adverse events were compared between pre- and post-examination periods.<h4>Results</h4>Eighty-six infants met the inclusion criteria. The score of abdominal distention increased from 2.0 at 1 day before examination to 2.3 at 1 day after examination (p = 0.005), and the number of infants who had worsened abdominal distension increased after examination (p = 0.01). Infants with lower body weight had a higher score of abdominal distention (p < 0.0001, r = -0.57). The number of infants with reduced milk consumption increased after examination (p = 0.0001), as did the number of infants with decreased pulse rate (p = 0.0008).<h4>Conclusions</h4>Screening for ROP with mydriatic may have adverse effects on systemic conditions. Infants should be carefully monitored after ROP screening with mydriatic.
format article
author Shumpei Obata
Taku Imamura
Masashi Kakinoki
Takahide Yanagi
Yoshihiro Maruo
Masahito Ohji
author_facet Shumpei Obata
Taku Imamura
Masashi Kakinoki
Takahide Yanagi
Yoshihiro Maruo
Masahito Ohji
author_sort Shumpei Obata
title Systemic adverse events after screening of retinopathy of prematurity with mydriatic.
title_short Systemic adverse events after screening of retinopathy of prematurity with mydriatic.
title_full Systemic adverse events after screening of retinopathy of prematurity with mydriatic.
title_fullStr Systemic adverse events after screening of retinopathy of prematurity with mydriatic.
title_full_unstemmed Systemic adverse events after screening of retinopathy of prematurity with mydriatic.
title_sort systemic adverse events after screening of retinopathy of prematurity with mydriatic.
publisher Public Library of Science (PLoS)
publishDate 2021
url https://doaj.org/article/63249ec9cc314c6399bf23de97ee17a6
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AT takahideyanagi systemicadverseeventsafterscreeningofretinopathyofprematuritywithmydriatic
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