A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia

Background: Peri-operative shivering a challenging discomfort faced in anesthesiologists’ daily practice. Many drugs were used as a prophylaxis, but there was no consensus on ideal or standard drug yet. Aim of the work: To compare the effectiveness and safety of pethidine, granisetron and tramadol i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Yousry Abdelsalam
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2020
Materias:	spinal anesthesia regional anesthesia tramadol pethidine granisetron Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/6325b48e0f7842fc80af91d46dcd0f32
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6325b48e0f7842fc80af91d46dcd0f32
record_format	dspace
spelling	oai:doaj.org-article:6325b48e0f7842fc80af91d46dcd0f322021-12-02T14:02:01ZA comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia2636-41742682-378010.21608/ijma.2020.19679.1044https://doaj.org/article/6325b48e0f7842fc80af91d46dcd0f322020-01-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_69646_6fb1c7ac4e9fa6c5ee30aef81b097cd4.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Background: Peri-operative shivering a challenging discomfort faced in anesthesiologists’ daily practice. Many drugs were used as a prophylaxis, but there was no consensus on ideal or standard drug yet. Aim of the work: To compare the effectiveness and safety of pethidine, granisetron and tramadol in prophylaxis against perioperative shivering after spinal anesthesia. Patients and methods: Sixty adult patients, who underwent spinal anesthesia, were included. They were randomly assigned to granisetron, pethidine or tramadol (20 in each group), and submitted to standard intraoperative monitoring and follow up for postoperative 4 hours. Monitoring included electrocardiography, oxygen saturation, respiratory rate, temperature, non-invasive blood level, conscious level and sedation score. Side effects were documented. Results: Intra- and post-operatively, there was significant reduction of heart rate in granisetron and tramadol groups. Mean arterial pressure significantly decreased in granisetron group at the time from 30 minutes to the end of surgery and during the first two postoperative hours. Respiratory rate significantly decreased in pethidine group during the complete intra- and post-operative period. Granisetron had no sedative effect at all, but sedation was significantly increased among pethidine group. Finally, perioperative shivering was reported in 25%, 15% and 15% of pethidine, granisetron and tramadol groups respectively. Nausea/vomiting was reported in 20%, 10.0%, and 0% of pethidine, tramadol and granisetron groups respectively. Pruritus was confined to 30% pethidine group with significant difference. Conclusion: Granisetron, tramadol and pethidine, all are effective as a prophylaxis against perioperative shivering after spinal anesthesia. However, granisetron seems to be the most suitable drug.Yousry AbdelsalamAl-Azhar University, Faculty of Medicine (Damietta)articlespinal anesthesiaregional anesthesiatramadolpethidinegranisetronMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 2, Iss 1, Pp 292-300 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	spinal anesthesia regional anesthesia tramadol pethidine granisetron Medicine (General) R5-920
spellingShingle	spinal anesthesia regional anesthesia tramadol pethidine granisetron Medicine (General) R5-920 Yousry Abdelsalam A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia
description	Background: Peri-operative shivering a challenging discomfort faced in anesthesiologists’ daily practice. Many drugs were used as a prophylaxis, but there was no consensus on ideal or standard drug yet. Aim of the work: To compare the effectiveness and safety of pethidine, granisetron and tramadol in prophylaxis against perioperative shivering after spinal anesthesia. Patients and methods: Sixty adult patients, who underwent spinal anesthesia, were included. They were randomly assigned to granisetron, pethidine or tramadol (20 in each group), and submitted to standard intraoperative monitoring and follow up for postoperative 4 hours. Monitoring included electrocardiography, oxygen saturation, respiratory rate, temperature, non-invasive blood level, conscious level and sedation score. Side effects were documented. Results: Intra- and post-operatively, there was significant reduction of heart rate in granisetron and tramadol groups. Mean arterial pressure significantly decreased in granisetron group at the time from 30 minutes to the end of surgery and during the first two postoperative hours. Respiratory rate significantly decreased in pethidine group during the complete intra- and post-operative period. Granisetron had no sedative effect at all, but sedation was significantly increased among pethidine group. Finally, perioperative shivering was reported in 25%, 15% and 15% of pethidine, granisetron and tramadol groups respectively. Nausea/vomiting was reported in 20%, 10.0%, and 0% of pethidine, tramadol and granisetron groups respectively. Pruritus was confined to 30% pethidine group with significant difference. Conclusion: Granisetron, tramadol and pethidine, all are effective as a prophylaxis against perioperative shivering after spinal anesthesia. However, granisetron seems to be the most suitable drug.
format	article
author	Yousry Abdelsalam
author_facet	Yousry Abdelsalam
author_sort	Yousry Abdelsalam
title	A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia
title_short	A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia
title_full	A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia
title_fullStr	A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia
title_full_unstemmed	A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia
title_sort	comparative study between pethidine, granisetron and tramadol in prophylaxis against perioperative shivering after spinal anesthesia
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2020
url	https://doaj.org/article/6325b48e0f7842fc80af91d46dcd0f32
work_keys_str_mv	AT yousryabdelsalam acomparativestudybetweenpethidinegranisetronandtramadolinprophylaxisagainstperioperativeshiveringafterspinalanesthesia AT yousryabdelsalam comparativestudybetweenpethidinegranisetronandtramadolinprophylaxisagainstperioperativeshiveringafterspinalanesthesia
_version_	1718392083331416064

A comparative Study Between Pethidine, Granisetron and Tramadol in Prophylaxis Against Perioperative Shivering After Spinal Anesthesia

Ejemplares similares