The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description

Some issues are extremely simple if looked at without prejudice. This is also true for carcinomas. Carcinomas are malignant neoplasms of epithelial cells. Where are they going to arise? In the epithelium. Therefore, at the outset, they must be confined to the epithelium. How are they going to look...

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Autor principal:	Wolfgang Weyers
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2012
Materias:	Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/632729b6c90e43af8080416db37da9f4
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spelling	oai:doaj.org-article:632729b6c90e43af8080416db37da9f42021-11-17T08:33:01ZThe centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description10.5826/dpc.0204a022160-9381https://doaj.org/article/632729b6c90e43af8080416db37da9f42012-10-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/979https://doaj.org/toc/2160-9381 Some issues are extremely simple if looked at without prejudice. This is also true for carcinomas. Carcinomas are malignant neoplasms of epithelial cells. Where are they going to arise? In the epithelium. Therefore, at the outset, they must be confined to the epithelium. How are they going to look in the beginning? Small and inconspicuous. How are they going to develop? They will grow and unfold the capacities with which they are endowed unless they are destroyed. This is nothing special but true for every living matter. But unprejudiced reflection is difficult because we all adopt conceptions of our time that channel our thinking. For many centuries, carcinomas were never treated before they had metastasized. Recurrences were soon to occur, and most patients died shortly after seeking treatment. The incurability of cancer was so deeply rooted in the worldview of physicians that the diagnosis of cancer was always challenged when a patient survived. Because carcinomas were excised only in stages far advanced, the bulk of the tumor was present in the dermis or deeper structures. That circumstance prompted Rudolf Virchow in 1855 to suggest derivation of carcinomas from cells of connective tissue, a concept to which he adhered for many years afterward. In 1865, Carl Thiersch proved the epithelial origin of cancer, but he believed that the true reason for the epithelial proliferation was a pathological weakness of the connective tissue that enabled sprouts of epithelium to grow in. As late as in 1894, Hugo Ribbert averred that carcinomas did not result from growth of epithelium into connective tissue but from growth of connective tissue into the overlying epithelium [1]. Wolfgang WeyersMattioli1885articleDermatologyRL1-803ENDermatology Practical & Conceptual (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Dermatology RL1-803
spellingShingle	Dermatology RL1-803 Wolfgang Weyers The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description
description	Some issues are extremely simple if looked at without prejudice. This is also true for carcinomas. Carcinomas are malignant neoplasms of epithelial cells. Where are they going to arise? In the epithelium. Therefore, at the outset, they must be confined to the epithelium. How are they going to look in the beginning? Small and inconspicuous. How are they going to develop? They will grow and unfold the capacities with which they are endowed unless they are destroyed. This is nothing special but true for every living matter. But unprejudiced reflection is difficult because we all adopt conceptions of our time that channel our thinking. For many centuries, carcinomas were never treated before they had metastasized. Recurrences were soon to occur, and most patients died shortly after seeking treatment. The incurability of cancer was so deeply rooted in the worldview of physicians that the diagnosis of cancer was always challenged when a patient survived. Because carcinomas were excised only in stages far advanced, the bulk of the tumor was present in the dermis or deeper structures. That circumstance prompted Rudolf Virchow in 1855 to suggest derivation of carcinomas from cells of connective tissue, a concept to which he adhered for many years afterward. In 1865, Carl Thiersch proved the epithelial origin of cancer, but he believed that the true reason for the epithelial proliferation was a pathological weakness of the connective tissue that enabled sprouts of epithelium to grow in. As late as in 1894, Hugo Ribbert averred that carcinomas did not result from growth of epithelium into connective tissue but from growth of connective tissue into the overlying epithelium [1].
format	article
author	Wolfgang Weyers
author_facet	Wolfgang Weyers
author_sort	Wolfgang Weyers
title	The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description
title_short	The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description
title_full	The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description
title_fullStr	The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description
title_full_unstemmed	The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description
title_sort	centennial of bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description
publisher	Mattioli1885
publishDate	2012
url	https://doaj.org/article/632729b6c90e43af8080416db37da9f4
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The centennial of Bowen’s disease—a critical review on the occasion of the 100th anniversary of its original description

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