Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.
Prostaglandin E2 receptor EP4 is involved in inflammation and related tumorigenesis in the colorectum. This study aimed to investigate the chemopreventive ability of RQ-15986, a selective EP4 antagonist, in colitis-related colorectal tumorigenesis. Male Kyoto APC delta rats, which have APC mutations...
Guardado en:
Autores principales: | Yohei Shirakami, Takayuki Nakanishi, Noritaka Ozawa, Takayasu Ideta, Takahiro Kochi, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/632ca27268e34ffbae3aa9cd0de6aa1e |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
- RQ
-
Novel FXR agonist nelumal A suppresses colitis and inflammation-related colorectal carcinogenesis
por: Tsuneyuki Miyazaki, et al.
Publicado: (2021) -
Apc mutation enhances PyMT-induced mammary tumorigenesis.
por: Jenifer R Prosperi, et al.
Publicado: (2011) -
Epithelial-derived IL-33 promotes intestinal tumorigenesis in Apc Min/+ mice
por: Zhengxiang He, et al.
Publicado: (2017) -
Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis
por: Tao Han, et al.
Publicado: (2019)