Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons.
The molecular triggers for axon degeneration remain unknown. We identify endogenous Nmnat2 as a labile axon survival factor whose constant replenishment by anterograde axonal transport is a limiting factor for axon survival. Specific depletion of Nmnat2 is sufficient to induce Wallerian-like degener...
Guardado en:
Autores principales: | Jonathan Gilley, Michael P Coleman |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Public Library of Science (PLoS)
2010
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Materias: | |
Acceso en línea: | https://doaj.org/article/632fc2e9aedc4d568fd9d42964dccb81 |
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