Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis

Cutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long a...

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Autores principales:	Silvia González-Martínez, David Pizarro, Belén Pérez-Mies, Tamara Caniego-Casas, Giuseppe Curigliano, Javier Cortés, José Palacios
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	breast cancer metastasis skin pathology immunohistochemistry mutation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/633030240f00426e8b275e87abb0fd03
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spelling	oai:doaj.org-article:633030240f00426e8b275e87abb0fd032021-11-11T15:30:48ZClinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis10.3390/cancers132154162072-6694https://doaj.org/article/633030240f00426e8b275e87abb0fd032021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5416https://doaj.org/toc/2072-6694Cutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long after development of the primary tumor. In addition, the molecular differences between the primary tumors and their CMs, and between CMs and metastases in other organs, are not well defined. Here, we review the main clinical, pathological, and molecular characteristics of breast cancer CMs. Identifying molecular markers in primary BC that predict CM and can be used to determine the molecular differences between primary tumors and their metastases is of great interest for the design of new therapeutic approaches.Silvia González-MartínezDavid PizarroBelén Pérez-MiesTamara Caniego-CasasGiuseppe CuriglianoJavier CortésJosé PalaciosMDPI AGarticlebreast cancermetastasisskinpathologyimmunohistochemistrymutationNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5416, p 5416 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast cancer metastasis skin pathology immunohistochemistry mutation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast cancer metastasis skin pathology immunohistochemistry mutation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Silvia González-Martínez David Pizarro Belén Pérez-Mies Tamara Caniego-Casas Giuseppe Curigliano Javier Cortés José Palacios Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis
description	Cutaneous metastases (CMs) account for 2% of all skin malignancies, and nearly 70% of CMs in women originate from breast cancer (BC). CMs are usually associated with poor prognosis, are difficult to treat, and can pose diagnostic problems, such as in histopathological diagnosis when occurring long after development of the primary tumor. In addition, the molecular differences between the primary tumors and their CMs, and between CMs and metastases in other organs, are not well defined. Here, we review the main clinical, pathological, and molecular characteristics of breast cancer CMs. Identifying molecular markers in primary BC that predict CM and can be used to determine the molecular differences between primary tumors and their metastases is of great interest for the design of new therapeutic approaches.
format	article
author	Silvia González-Martínez David Pizarro Belén Pérez-Mies Tamara Caniego-Casas Giuseppe Curigliano Javier Cortés José Palacios
author_facet	Silvia González-Martínez David Pizarro Belén Pérez-Mies Tamara Caniego-Casas Giuseppe Curigliano Javier Cortés José Palacios
author_sort	Silvia González-Martínez
title	Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis
title_short	Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis
title_full	Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis
title_fullStr	Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis
title_full_unstemmed	Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis
title_sort	clinical, pathological, and molecular features of breast carcinoma cutaneous metastasis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/633030240f00426e8b275e87abb0fd03
work_keys_str_mv	AT silviagonzalezmartinez clinicalpathologicalandmolecularfeaturesofbreastcarcinomacutaneousmetastasis AT davidpizarro clinicalpathologicalandmolecularfeaturesofbreastcarcinomacutaneousmetastasis AT belenperezmies clinicalpathologicalandmolecularfeaturesofbreastcarcinomacutaneousmetastasis AT tamaracaniegocasas clinicalpathologicalandmolecularfeaturesofbreastcarcinomacutaneousmetastasis AT giuseppecurigliano clinicalpathologicalandmolecularfeaturesofbreastcarcinomacutaneousmetastasis AT javiercortes clinicalpathologicalandmolecularfeaturesofbreastcarcinomacutaneousmetastasis AT josepalacios clinicalpathologicalandmolecularfeaturesofbreastcarcinomacutaneousmetastasis
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Clinical, Pathological, and Molecular Features of Breast Carcinoma Cutaneous Metastasis

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