Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer
Abstract Colorectal cancer is the third most frequently diagnosed cancer malignancy and the second leading cause of cancer-related deaths worldwide. Therefore, it is of utmost importance to provide new therapeutic options that can improve survival. Sphingomyelin nanosystems (SNs) are a promising typ...
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Nature Portfolio
2021
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oai:doaj.org-article:63332139058d49b2bcb04ce39b1172062021-12-02T18:53:09ZSphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer10.1038/s41598-021-96578-z2045-2322https://doaj.org/article/63332139058d49b2bcb04ce39b1172062021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96578-zhttps://doaj.org/toc/2045-2322Abstract Colorectal cancer is the third most frequently diagnosed cancer malignancy and the second leading cause of cancer-related deaths worldwide. Therefore, it is of utmost importance to provide new therapeutic options that can improve survival. Sphingomyelin nanosystems (SNs) are a promising type of nanocarriers with potential for association of different types of drugs and, thus, for the development of combination treatments. In this work we propose the chemical modification of uroguanylin, a natural ligand for the Guanylyl Cyclase (GCC) receptor, expressed in metastatic colorectal cancer tumors, to favour its anchoring to SNs (UroGm-SNs). The anti-cancer drug etoposide (Etp) was additionally encapsulated for the development of a combination strategy (UroGm-Etp-SNs). Results from in vitro studies showed that UroGm-Etp-SNs can interact with colorectal cancer cells that express the GCC receptor and mediate an antiproliferative response, which is more remarkable for the drugs in combination. The potential of UroGm-Etp-SNs to treat metastatic colorectal cancer cells was complemented with an in vivo experiment in a xenograft mice model.Belén L. BouzoSaínza LoresRaneem JatalSandra AlijasMaría José AlonsoInmaculada Conejos-SánchezMaría de la FuenteNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Belén L. Bouzo Saínza Lores Raneem Jatal Sandra Alijas María José Alonso Inmaculada Conejos-Sánchez María de la Fuente Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer |
| description |
Abstract Colorectal cancer is the third most frequently diagnosed cancer malignancy and the second leading cause of cancer-related deaths worldwide. Therefore, it is of utmost importance to provide new therapeutic options that can improve survival. Sphingomyelin nanosystems (SNs) are a promising type of nanocarriers with potential for association of different types of drugs and, thus, for the development of combination treatments. In this work we propose the chemical modification of uroguanylin, a natural ligand for the Guanylyl Cyclase (GCC) receptor, expressed in metastatic colorectal cancer tumors, to favour its anchoring to SNs (UroGm-SNs). The anti-cancer drug etoposide (Etp) was additionally encapsulated for the development of a combination strategy (UroGm-Etp-SNs). Results from in vitro studies showed that UroGm-Etp-SNs can interact with colorectal cancer cells that express the GCC receptor and mediate an antiproliferative response, which is more remarkable for the drugs in combination. The potential of UroGm-Etp-SNs to treat metastatic colorectal cancer cells was complemented with an in vivo experiment in a xenograft mice model. |
| format |
article |
| author |
Belén L. Bouzo Saínza Lores Raneem Jatal Sandra Alijas María José Alonso Inmaculada Conejos-Sánchez María de la Fuente |
| author_facet |
Belén L. Bouzo Saínza Lores Raneem Jatal Sandra Alijas María José Alonso Inmaculada Conejos-Sánchez María de la Fuente |
| author_sort |
Belén L. Bouzo |
| title |
Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer |
| title_short |
Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer |
| title_full |
Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer |
| title_fullStr |
Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer |
| title_full_unstemmed |
Sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer |
| title_sort |
sphingomyelin nanosystems loaded with uroguanylin and etoposide for treating metastatic colorectal cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/63332139058d49b2bcb04ce39b117206 |
| work_keys_str_mv |
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