Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics

Joseph S Bertino Jr1,21College of Physicians and Surgeons, Columbia University, New York, N Y, USA; 2Principal, Bertino Consulting, Schenectady, NY, USAPurpose: This article reviews the effects of the increase in bacterial resistance on the treatment of ocular infections.Design: Interpretive assessm...

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Autor principal:	Joseph S Bertino Jr
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2009
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/633455da46fc4f14879faff25c39e9f6
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spelling	oai:doaj.org-article:633455da46fc4f14879faff25c39e9f62021-12-02T07:27:40ZImpact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics1177-54671177-5483https://doaj.org/article/633455da46fc4f14879faff25c39e9f62009-09-01T00:00:00Zhttp://www.dovepress.com/impact-of-antibiotic-resistance-in-the-management-of-ocular-infections-a3549https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Joseph S Bertino Jr1,21College of Physicians and Surgeons, Columbia University, New York, N Y, USA; 2Principal, Bertino Consulting, Schenectady, NY, USAPurpose: This article reviews the effects of the increase in bacterial resistance on the treatment of ocular infections.Design: Interpretive assessment.Methods: Literature review and interpretation.Results: Ocular bacterial infections include conjunctivitis, keratitis, endophthalmitis, blepharitis, orbital cellulitis, and dacryocystitis. Treatment for most ocular bacterial infections is primarily empiric with broad-spectrum antibiotics, which are effective against the most common bacteria associated with these ocular infections. However, the widespread use of broad-spectrum systemic antibiotics has resulted in a global increase in resistance among both Gram-positive and Gram-negative bacteria to a number of the older antibiotics as well as some of the newer fluoroquinolones used to treat ophthalmic infections. Strategies for the prevention of the increase in ocular pathogen resistance should be developed and implemented. In addition, new antimicrobial agents with optimized pharmacokinetic and pharmacodynamic properties that have low toxicity, high efficacy, and reduced potential for the development of resistance are needed.Conclusions: New antimicrobial agents that treat ocular infections effectively and have a low potential for the development of resistance could be a part of strategies to prevent the global increase in ocular pathogen resistance.Keywords: ocular infections, emerging pathogen drug resistance, fluoroquinolones, besifloxacin Joseph S Bertino JrDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2009, Iss default, Pp 507-521 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Joseph S Bertino Jr Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics
description	Joseph S Bertino Jr1,21College of Physicians and Surgeons, Columbia University, New York, N Y, USA; 2Principal, Bertino Consulting, Schenectady, NY, USAPurpose: This article reviews the effects of the increase in bacterial resistance on the treatment of ocular infections.Design: Interpretive assessment.Methods: Literature review and interpretation.Results: Ocular bacterial infections include conjunctivitis, keratitis, endophthalmitis, blepharitis, orbital cellulitis, and dacryocystitis. Treatment for most ocular bacterial infections is primarily empiric with broad-spectrum antibiotics, which are effective against the most common bacteria associated with these ocular infections. However, the widespread use of broad-spectrum systemic antibiotics has resulted in a global increase in resistance among both Gram-positive and Gram-negative bacteria to a number of the older antibiotics as well as some of the newer fluoroquinolones used to treat ophthalmic infections. Strategies for the prevention of the increase in ocular pathogen resistance should be developed and implemented. In addition, new antimicrobial agents with optimized pharmacokinetic and pharmacodynamic properties that have low toxicity, high efficacy, and reduced potential for the development of resistance are needed.Conclusions: New antimicrobial agents that treat ocular infections effectively and have a low potential for the development of resistance could be a part of strategies to prevent the global increase in ocular pathogen resistance.Keywords: ocular infections, emerging pathogen drug resistance, fluoroquinolones, besifloxacin
format	article
author	Joseph S Bertino Jr
author_facet	Joseph S Bertino Jr
author_sort	Joseph S Bertino Jr
title	Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics
title_short	Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics
title_full	Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics
title_fullStr	Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics
title_full_unstemmed	Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics
title_sort	impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics
publisher	Dove Medical Press
publishDate	2009
url	https://doaj.org/article/633455da46fc4f14879faff25c39e9f6
work_keys_str_mv	AT josephsbertinojr impactofantibioticresistanceinthemanagementofocularinfectionstheroleofcurrentandfutureantibiotics
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Impact of antibiotic resistance in the management of ocular infections: the role of current and future antibiotics

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