Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy r...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alex H. Wagner, Siddhartha Devarakonda, Zachary L. Skidmore, Kilannin Krysiak, Avinash Ramu, Lee Trani, Jason Kunisaki, Ashiq Masood, Saiama N. Waqar, Nicholas C. Spies, Daniel Morgensztern, Jason Waligorski, Jennifer Ponce, Robert S. Fulton, Leonard B. Maggi, Jason D. Weber, Mark A. Watson, Christopher J. O’Conor, Jon H. Ritter, Rachelle R. Olsen, Haixia Cheng, Anandaroop Mukhopadhyay, Ismail Can, Melissa H. Cessna, Trudy G. Oliver, Elaine R. Mardis, Richard K. Wilson, Malachi Griffith, Obi L. Griffith, Ramaswamy Govindan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/633460ab94c74c7ba9529694b90819e7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:633460ab94c74c7ba9529694b90819e7
record_format	dspace
spelling	oai:doaj.org-article:633460ab94c74c7ba9529694b90819e72021-12-02T17:31:15ZRecurrent WNT pathway alterations are frequent in relapsed small cell lung cancer10.1038/s41467-018-06162-92041-1723https://doaj.org/article/633460ab94c74c7ba9529694b90819e72018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06162-9https://doaj.org/toc/2041-1723Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.Alex H. WagnerSiddhartha DevarakondaZachary L. SkidmoreKilannin KrysiakAvinash RamuLee TraniJason KunisakiAshiq MasoodSaiama N. WaqarNicholas C. SpiesDaniel MorgenszternJason WaligorskiJennifer PonceRobert S. FultonLeonard B. MaggiJason D. WeberMark A. WatsonChristopher J. O’ConorJon H. RitterRachelle R. OlsenHaixia ChengAnandaroop MukhopadhyayIsmail CanMelissa H. CessnaTrudy G. OliverElaine R. MardisRichard K. WilsonMalachi GriffithObi L. GriffithRamaswamy GovindanNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alex H. Wagner Siddhartha Devarakonda Zachary L. Skidmore Kilannin Krysiak Avinash Ramu Lee Trani Jason Kunisaki Ashiq Masood Saiama N. Waqar Nicholas C. Spies Daniel Morgensztern Jason Waligorski Jennifer Ponce Robert S. Fulton Leonard B. Maggi Jason D. Weber Mark A. Watson Christopher J. O’Conor Jon H. Ritter Rachelle R. Olsen Haixia Cheng Anandaroop Mukhopadhyay Ismail Can Melissa H. Cessna Trudy G. Oliver Elaine R. Mardis Richard K. Wilson Malachi Griffith Obi L. Griffith Ramaswamy Govindan Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
description	Small cell lung cancer (SCLC) patients frequently relapse and become resistant to chemotherapy. Here, the authors analyse the genomic and transcriptomic landscape of primary and relapsed SCLC patients as well as in vitro models, and discover that activation of WNT signalling can drive chemotherapy resistance.
format	article
author	Alex H. Wagner Siddhartha Devarakonda Zachary L. Skidmore Kilannin Krysiak Avinash Ramu Lee Trani Jason Kunisaki Ashiq Masood Saiama N. Waqar Nicholas C. Spies Daniel Morgensztern Jason Waligorski Jennifer Ponce Robert S. Fulton Leonard B. Maggi Jason D. Weber Mark A. Watson Christopher J. O’Conor Jon H. Ritter Rachelle R. Olsen Haixia Cheng Anandaroop Mukhopadhyay Ismail Can Melissa H. Cessna Trudy G. Oliver Elaine R. Mardis Richard K. Wilson Malachi Griffith Obi L. Griffith Ramaswamy Govindan
author_facet	Alex H. Wagner Siddhartha Devarakonda Zachary L. Skidmore Kilannin Krysiak Avinash Ramu Lee Trani Jason Kunisaki Ashiq Masood Saiama N. Waqar Nicholas C. Spies Daniel Morgensztern Jason Waligorski Jennifer Ponce Robert S. Fulton Leonard B. Maggi Jason D. Weber Mark A. Watson Christopher J. O’Conor Jon H. Ritter Rachelle R. Olsen Haixia Cheng Anandaroop Mukhopadhyay Ismail Can Melissa H. Cessna Trudy G. Oliver Elaine R. Mardis Richard K. Wilson Malachi Griffith Obi L. Griffith Ramaswamy Govindan
author_sort	Alex H. Wagner
title	Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
title_short	Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
title_full	Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
title_fullStr	Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
title_full_unstemmed	Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer
title_sort	recurrent wnt pathway alterations are frequent in relapsed small cell lung cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/633460ab94c74c7ba9529694b90819e7
work_keys_str_mv	AT alexhwagner recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT siddharthadevarakonda recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT zacharylskidmore recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT kilanninkrysiak recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT avinashramu recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT leetrani recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT jasonkunisaki recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT ashiqmasood recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT saiamanwaqar recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT nicholascspies recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT danielmorgensztern recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT jasonwaligorski recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT jenniferponce recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT robertsfulton recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT leonardbmaggi recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT jasondweber recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT markawatson recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT christopherjoconor recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT jonhritter recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT rachellerolsen recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT haixiacheng recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT anandaroopmukhopadhyay recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT ismailcan recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT melissahcessna recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT trudygoliver recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT elainermardis recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT richardkwilson recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT malachigriffith recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT obilgriffith recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer AT ramaswamygovindan recurrentwntpathwayalterationsarefrequentinrelapsedsmallcelllungcancer
_version_	1718380675272278016

Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer

Ejemplares similares