Human <italic toggle="yes">V<sub>H</sub>1-69</italic> Gene-Encoded Human Monoclonal Antibodies against <named-content content-type="genus-species">Staphylococcus aureus</named-content> IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis

Human <italic toggle="yes">V<sub>H</sub>1-69</italic> Gene-Encoded Human Monoclonal Antibodies against <named-content content-type="genus-species">Staphylococcus aureus</named-content> IsdB Use at Least Three Distinct Modes of Binding To Inhibit Bacterial Growth and Pathogenesis

ABSTRACT Staphylococcus aureus is an important human pathogen that infects nearly every human tissue. Like most organisms, the acquisition of nutrient iron is necessary for its survival. One route by which it obtains this metal is through the iron-regulated surface determinant (Isd) system that scav...

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Detalles Bibliográficos
Autores principales: Monique R. Bennett, Jinhui Dong, Robin G. Bombardi, Cinque Soto, Helen M. Parrington, Rachel S. Nargi, Clara T. Schoeder, Marcus B. Nagel, Kevin L. Schey, Jens Meiler, Eric P. Skaar, James E. Crowe
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Staphylococcus aureus
X-ray crystallography
adaptive immunity
antibody functions
antibody repertoire
computer modeling
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/633528a5968b43209963b3d7f2daa1df
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