Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as well as superior visual pattern discrimination.

Guardado en:

Detalles Bibliográficos
Autores principales:	Michael H. Berry, Amy Holt, Joshua Levitz, Johannes Broichhagen, Benjamin M. Gaub, Meike Visel, Cherise Stanley, Krishan Aghi, Yang Joon Kim, Kevin Cao, Richard H. Kramer, Dirk Trauner, John Flannery, Ehud Y. Isacoff
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/633814130c744076adf5b920ac4c46b7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:633814130c744076adf5b920ac4c46b7
record_format	dspace
spelling	oai:doaj.org-article:633814130c744076adf5b920ac4c46b72021-12-02T14:42:38ZRestoration of patterned vision with an engineered photoactivatable G protein-coupled receptor10.1038/s41467-017-01990-72041-1723https://doaj.org/article/633814130c744076adf5b920ac4c46b72017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01990-7https://doaj.org/toc/2041-1723To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as well as superior visual pattern discrimination.Michael H. BerryAmy HoltJoshua LevitzJohannes BroichhagenBenjamin M. GaubMeike ViselCherise StanleyKrishan AghiYang Joon KimKevin CaoRichard H. KramerDirk TraunerJohn FlanneryEhud Y. IsacoffNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael H. Berry Amy Holt Joshua Levitz Johannes Broichhagen Benjamin M. Gaub Meike Visel Cherise Stanley Krishan Aghi Yang Joon Kim Kevin Cao Richard H. Kramer Dirk Trauner John Flannery Ehud Y. Isacoff Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
description	To restore sight after retinal degeneration, one approach is to express light-sensitive proteins in remaining cells. Here the authors combine a light-sensitive engineered G protein-coupled receptor and ion channels to restore ON and OFF responses as well as superior visual pattern discrimination.
format	article
author	Michael H. Berry Amy Holt Joshua Levitz Johannes Broichhagen Benjamin M. Gaub Meike Visel Cherise Stanley Krishan Aghi Yang Joon Kim Kevin Cao Richard H. Kramer Dirk Trauner John Flannery Ehud Y. Isacoff
author_facet	Michael H. Berry Amy Holt Joshua Levitz Johannes Broichhagen Benjamin M. Gaub Meike Visel Cherise Stanley Krishan Aghi Yang Joon Kim Kevin Cao Richard H. Kramer Dirk Trauner John Flannery Ehud Y. Isacoff
author_sort	Michael H. Berry
title	Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
title_short	Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
title_full	Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
title_fullStr	Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
title_full_unstemmed	Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor
title_sort	restoration of patterned vision with an engineered photoactivatable g protein-coupled receptor
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/633814130c744076adf5b920ac4c46b7
work_keys_str_mv	AT michaelhberry restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT amyholt restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT joshualevitz restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT johannesbroichhagen restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT benjaminmgaub restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT meikevisel restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT cherisestanley restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT krishanaghi restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT yangjoonkim restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT kevincao restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT richardhkramer restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT dirktrauner restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT johnflannery restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor AT ehudyisacoff restorationofpatternedvisionwithanengineeredphotoactivatablegproteincoupledreceptor
_version_	1718389632000851968

Restoration of patterned vision with an engineered photoactivatable G protein-coupled receptor

Ejemplares similares