Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis
Abstract Transcatheter aortic valve replacement (TAVR) has shown to reduce mortality compared to surgical aortic valve replacement (sAVR). However, it is unknown which procedure is associated with better post-procedural valvular function. We conducted a meta-analysis of randomized clinical trials th...
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Nature Portfolio
2021
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oai:doaj.org-article:63396efa1fb945da87ff182861c992992021-12-02T17:47:36ZAortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis10.1038/s41598-021-91548-x2045-2322https://doaj.org/article/63396efa1fb945da87ff182861c992992021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91548-xhttps://doaj.org/toc/2045-2322Abstract Transcatheter aortic valve replacement (TAVR) has shown to reduce mortality compared to surgical aortic valve replacement (sAVR). However, it is unknown which procedure is associated with better post-procedural valvular function. We conducted a meta-analysis of randomized clinical trials that compared TAVR to sAVR for at least 2 years. The primary outcome was post-procedural patient-prosthesis-mismatch (PPM). Secondary outcomes were post-procedural and 2-year: effective orifice area (EOA), paravalvular gradient (PVG) and moderate/severe paravalvular leak (PVL). We identified 6 trials with a total of 7022 participants with severe aortic stenosis. TAVR was associated with 37% (95% CI [0.51–0.78) mean RR reduction of post-procedural PPM, a decrease that was not affected by the surgical risk at inclusion, neither by the transcatheter heart valve system. Postprocedural changes in gradient and EOA were also in favor of TAVR as there was a pooled mean difference decrease of 0.56 (95% CI [0.73–0.38]) in gradient and an increase of 0.47 (95% CI [0.38–0.56]) in EOA. Additionally, self-expandable valves were associated with a higher decrease in gradient than balloon ones (beta = 0.38; 95% CI [0.12–0.64]). However, TAVR was associated with a higher risk of moderate/severe PVL (pooled RR: 9.54, 95% CI [5.53–16.46]). All results were sustainable at 2 years.Charbel Abi KhalilBarbara IgnatiukGuliz ErdemHiam ChemaitellyFabio BarilliMohamed El-ShazlyJassim Al SuwaidiSamar AboulsoudMarkus KoflerLukas StastnyHani JneidNikolaos BonarosNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
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Medicine R Science Q Charbel Abi Khalil Barbara Ignatiuk Guliz Erdem Hiam Chemaitelly Fabio Barilli Mohamed El-Shazly Jassim Al Suwaidi Samar Aboulsoud Markus Kofler Lukas Stastny Hani Jneid Nikolaos Bonaros Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis |
| description |
Abstract Transcatheter aortic valve replacement (TAVR) has shown to reduce mortality compared to surgical aortic valve replacement (sAVR). However, it is unknown which procedure is associated with better post-procedural valvular function. We conducted a meta-analysis of randomized clinical trials that compared TAVR to sAVR for at least 2 years. The primary outcome was post-procedural patient-prosthesis-mismatch (PPM). Secondary outcomes were post-procedural and 2-year: effective orifice area (EOA), paravalvular gradient (PVG) and moderate/severe paravalvular leak (PVL). We identified 6 trials with a total of 7022 participants with severe aortic stenosis. TAVR was associated with 37% (95% CI [0.51–0.78) mean RR reduction of post-procedural PPM, a decrease that was not affected by the surgical risk at inclusion, neither by the transcatheter heart valve system. Postprocedural changes in gradient and EOA were also in favor of TAVR as there was a pooled mean difference decrease of 0.56 (95% CI [0.73–0.38]) in gradient and an increase of 0.47 (95% CI [0.38–0.56]) in EOA. Additionally, self-expandable valves were associated with a higher decrease in gradient than balloon ones (beta = 0.38; 95% CI [0.12–0.64]). However, TAVR was associated with a higher risk of moderate/severe PVL (pooled RR: 9.54, 95% CI [5.53–16.46]). All results were sustainable at 2 years. |
| format |
article |
| author |
Charbel Abi Khalil Barbara Ignatiuk Guliz Erdem Hiam Chemaitelly Fabio Barilli Mohamed El-Shazly Jassim Al Suwaidi Samar Aboulsoud Markus Kofler Lukas Stastny Hani Jneid Nikolaos Bonaros |
| author_facet |
Charbel Abi Khalil Barbara Ignatiuk Guliz Erdem Hiam Chemaitelly Fabio Barilli Mohamed El-Shazly Jassim Al Suwaidi Samar Aboulsoud Markus Kofler Lukas Stastny Hani Jneid Nikolaos Bonaros |
| author_sort |
Charbel Abi Khalil |
| title |
Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis |
| title_short |
Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis |
| title_full |
Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis |
| title_fullStr |
Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis |
| title_full_unstemmed |
Aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis |
| title_sort |
aortic valve function post-replacement of severe aortic stenosis by transcatheter procedure versus surgery: a systematic review and metanalysis |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/63396efa1fb945da87ff182861c99299 |
| work_keys_str_mv |
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