High Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease
Objective: To determine the association of perceived stress with coagulation function and their predictive values for clinical outcomes.Methods: This prospective cohort study derived from a cross-sectional study for investigating the psychological status of inpatients with suspicious coronary heart...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:633a4125ba3448fa98e2c82de7b0bd362021-12-01T13:32:29ZHigh Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease2297-055X10.3389/fcvm.2021.769857https://doaj.org/article/633a4125ba3448fa98e2c82de7b0bd362021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcvm.2021.769857/fullhttps://doaj.org/toc/2297-055XObjective: To determine the association of perceived stress with coagulation function and their predictive values for clinical outcomes.Methods: This prospective cohort study derived from a cross-sectional study for investigating the psychological status of inpatients with suspicious coronary heart disease (CHD). In this study, the 10-item Perceived Stress Scale (PSS-10) as an optional questionnaire was used to assess the severity of perceived stress. Coagulation function tests, such as activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen were measured within 1 h after admission. Furthermore, 241 patients with CHD out of 705 consecutive inpatients were included in the analyses and followed with a median of 26 months for the clinical outcomes.Results: The patients in high perceived stress status (PSS-10 score > 16) were with shorter APTT (36.71 vs. 38.45 s, p = 0.009). Shortened APTT ( ≤ 35.0 s) correlated with higher PSS-10 score (14.67 vs. 11.22, p = 0.003). The association of APTT with depression or anxiety was not found. Multiple linear models adjusting for PT estimated that every single point increase in PSS-10 was relevant to approximately 0.13 s decrease in APTT (p = 0.001) regardless of the type of CHD. APTT (every 5 s increase: hazard ratio (HR) 0.68 [0.47–0.99], p = 0.041) and perceived stress (every 5 points increase: HR 1.31 [1.09–1.58], p = 0.005) could predict the cardiovascular outcomes. However, both predictive values would decrease when they were simultaneously adjusted. After adjusting for the physical clinical features, the associated of perceived stress on cardiac (HR 1.25 [1.04–1.51], p = 0.020) and composite clinical outcomes (HR 1.24 [1.05–1.47], p = 0.011) persisted.Conclusions: For the patients with CHD, perceived stress strongly correlates with APTT. The activation of the intrinsic coagulation pathway is one of the mechanisms that high perceived stress causes cardiovascular events. This hints at an important role of the interaction of mental stress and coagulation function on cardiovascular prognosis. More attention needs to be paid to the patients with CHD with high perceived stress.Han YinXingyu ChengYanting LiangAnbang LiuHaochen WangHaochen WangFengyao LiuFengyao LiuLan GuoHuan MaQingshan GengQingshan GengFrontiers Media S.A.articleperceived stresscoronary heart diseaseactivated partial thromboplastin timeacute coronary syndromedepressionDiseases of the circulatory (Cardiovascular) systemRC666-701ENFrontiers in Cardiovascular Medicine, Vol 8 (2021) |
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perceived stress coronary heart disease activated partial thromboplastin time acute coronary syndrome depression Diseases of the circulatory (Cardiovascular) system RC666-701 |
| spellingShingle |
perceived stress coronary heart disease activated partial thromboplastin time acute coronary syndrome depression Diseases of the circulatory (Cardiovascular) system RC666-701 Han Yin Xingyu Cheng Yanting Liang Anbang Liu Haochen Wang Haochen Wang Fengyao Liu Fengyao Liu Lan Guo Huan Ma Qingshan Geng Qingshan Geng High Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease |
| description |
Objective: To determine the association of perceived stress with coagulation function and their predictive values for clinical outcomes.Methods: This prospective cohort study derived from a cross-sectional study for investigating the psychological status of inpatients with suspicious coronary heart disease (CHD). In this study, the 10-item Perceived Stress Scale (PSS-10) as an optional questionnaire was used to assess the severity of perceived stress. Coagulation function tests, such as activated partial thromboplastin time (APTT), prothrombin time (PT), and fibrinogen were measured within 1 h after admission. Furthermore, 241 patients with CHD out of 705 consecutive inpatients were included in the analyses and followed with a median of 26 months for the clinical outcomes.Results: The patients in high perceived stress status (PSS-10 score > 16) were with shorter APTT (36.71 vs. 38.45 s, p = 0.009). Shortened APTT ( ≤ 35.0 s) correlated with higher PSS-10 score (14.67 vs. 11.22, p = 0.003). The association of APTT with depression or anxiety was not found. Multiple linear models adjusting for PT estimated that every single point increase in PSS-10 was relevant to approximately 0.13 s decrease in APTT (p = 0.001) regardless of the type of CHD. APTT (every 5 s increase: hazard ratio (HR) 0.68 [0.47–0.99], p = 0.041) and perceived stress (every 5 points increase: HR 1.31 [1.09–1.58], p = 0.005) could predict the cardiovascular outcomes. However, both predictive values would decrease when they were simultaneously adjusted. After adjusting for the physical clinical features, the associated of perceived stress on cardiac (HR 1.25 [1.04–1.51], p = 0.020) and composite clinical outcomes (HR 1.24 [1.05–1.47], p = 0.011) persisted.Conclusions: For the patients with CHD, perceived stress strongly correlates with APTT. The activation of the intrinsic coagulation pathway is one of the mechanisms that high perceived stress causes cardiovascular events. This hints at an important role of the interaction of mental stress and coagulation function on cardiovascular prognosis. More attention needs to be paid to the patients with CHD with high perceived stress. |
| format |
article |
| author |
Han Yin Xingyu Cheng Yanting Liang Anbang Liu Haochen Wang Haochen Wang Fengyao Liu Fengyao Liu Lan Guo Huan Ma Qingshan Geng Qingshan Geng |
| author_facet |
Han Yin Xingyu Cheng Yanting Liang Anbang Liu Haochen Wang Haochen Wang Fengyao Liu Fengyao Liu Lan Guo Huan Ma Qingshan Geng Qingshan Geng |
| author_sort |
Han Yin |
| title |
High Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease |
| title_short |
High Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease |
| title_full |
High Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease |
| title_fullStr |
High Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease |
| title_full_unstemmed |
High Perceived Stress May Shorten Activated Partial Thromboplastin Time and Lead to Worse Clinical Outcomes in Patients With Coronary Heart Disease |
| title_sort |
high perceived stress may shorten activated partial thromboplastin time and lead to worse clinical outcomes in patients with coronary heart disease |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/633a4125ba3448fa98e2c82de7b0bd36 |
| work_keys_str_mv |
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