Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease

Abstract Type I interferon (IFN) plays a crucial role in innate and adaptive immunity, and aberrant IFN responses are involved in systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and dermatomyositis (DM). Type I IFNs can be induced by transcribed retrotransposons. The regulat...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yuko Kuriyama, Akira Shimizu, Saki Kanai, Daisuke Oikawa, Sei-ichiro Motegi, Fuminori Tokunaga, Osamu Ishikawa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/633fb43b43864195abf8380da0ad4197
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:633fb43b43864195abf8380da0ad4197
record_format	dspace
spelling	oai:doaj.org-article:633fb43b43864195abf8380da0ad41972021-12-05T12:15:29ZCoordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease10.1038/s41598-021-02522-62045-2322https://doaj.org/article/633fb43b43864195abf8380da0ad41972021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02522-6https://doaj.org/toc/2045-2322Abstract Type I interferon (IFN) plays a crucial role in innate and adaptive immunity, and aberrant IFN responses are involved in systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and dermatomyositis (DM). Type I IFNs can be induced by transcribed retrotransposons. The regulation of retrotransposons and type I IFN and the downstream IFN pathways in SLE, DM, and autoimmune blistering disease (AIBD) were investigated. The gene expression levels of retrotransposons, including LINE-1, type I-III IFNs, and IFN-stimulated genes (ISGs) in peripheral blood cells from patients with DM (n = 24), SLE (n = 19), AIBD (n = 14) and healthy controls (HCs, n = 10) were assessed by quantitative polymerase chain reaction. Upregulation of retrotransposons and IFNs was detected in DM patient samples, as is characteristic, compared to HCs; however, ISGs were not uniformly upregulated. In contrast, retrotransposons and IFNs, except for type II IFN, such as IFN-γ, were not upregulated in SLE. In AIBD, only some retrotransposons and type I interferons were upregulated. The DM, SLE, and AIBD samples showed coordinated expression of retrotransposons and type I IFNs and distinct spectra of IFN signaling. A positive correlation between LINE-1 and IFN-β1 was also detected in human cell lines. These factors may participate in the development of these autoimmune diseases.Yuko KuriyamaAkira ShimizuSaki KanaiDaisuke OikawaSei-ichiro MotegiFuminori TokunagaOsamu IshikawaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yuko Kuriyama Akira Shimizu Saki Kanai Daisuke Oikawa Sei-ichiro Motegi Fuminori Tokunaga Osamu Ishikawa Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease
description	Abstract Type I interferon (IFN) plays a crucial role in innate and adaptive immunity, and aberrant IFN responses are involved in systemic autoimmune diseases, such as systemic lupus erythematosus (SLE) and dermatomyositis (DM). Type I IFNs can be induced by transcribed retrotransposons. The regulation of retrotransposons and type I IFN and the downstream IFN pathways in SLE, DM, and autoimmune blistering disease (AIBD) were investigated. The gene expression levels of retrotransposons, including LINE-1, type I-III IFNs, and IFN-stimulated genes (ISGs) in peripheral blood cells from patients with DM (n = 24), SLE (n = 19), AIBD (n = 14) and healthy controls (HCs, n = 10) were assessed by quantitative polymerase chain reaction. Upregulation of retrotransposons and IFNs was detected in DM patient samples, as is characteristic, compared to HCs; however, ISGs were not uniformly upregulated. In contrast, retrotransposons and IFNs, except for type II IFN, such as IFN-γ, were not upregulated in SLE. In AIBD, only some retrotransposons and type I interferons were upregulated. The DM, SLE, and AIBD samples showed coordinated expression of retrotransposons and type I IFNs and distinct spectra of IFN signaling. A positive correlation between LINE-1 and IFN-β1 was also detected in human cell lines. These factors may participate in the development of these autoimmune diseases.
format	article
author	Yuko Kuriyama Akira Shimizu Saki Kanai Daisuke Oikawa Sei-ichiro Motegi Fuminori Tokunaga Osamu Ishikawa
author_facet	Yuko Kuriyama Akira Shimizu Saki Kanai Daisuke Oikawa Sei-ichiro Motegi Fuminori Tokunaga Osamu Ishikawa
author_sort	Yuko Kuriyama
title	Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease
title_short	Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease
title_full	Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease
title_fullStr	Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease
title_full_unstemmed	Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease
title_sort	coordination of retrotransposons and type i interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/633fb43b43864195abf8380da0ad4197
work_keys_str_mv	AT yukokuriyama coordinationofretrotransposonsandtypeiinterferonwithdistinctinterferonpathwaysindermatomyositissystemiclupuserythematosusandautoimmuneblisteringdisease AT akirashimizu coordinationofretrotransposonsandtypeiinterferonwithdistinctinterferonpathwaysindermatomyositissystemiclupuserythematosusandautoimmuneblisteringdisease AT sakikanai coordinationofretrotransposonsandtypeiinterferonwithdistinctinterferonpathwaysindermatomyositissystemiclupuserythematosusandautoimmuneblisteringdisease AT daisukeoikawa coordinationofretrotransposonsandtypeiinterferonwithdistinctinterferonpathwaysindermatomyositissystemiclupuserythematosusandautoimmuneblisteringdisease AT seiichiromotegi coordinationofretrotransposonsandtypeiinterferonwithdistinctinterferonpathwaysindermatomyositissystemiclupuserythematosusandautoimmuneblisteringdisease AT fuminoritokunaga coordinationofretrotransposonsandtypeiinterferonwithdistinctinterferonpathwaysindermatomyositissystemiclupuserythematosusandautoimmuneblisteringdisease AT osamuishikawa coordinationofretrotransposonsandtypeiinterferonwithdistinctinterferonpathwaysindermatomyositissystemiclupuserythematosusandautoimmuneblisteringdisease
_version_	1718372076612485120

Coordination of retrotransposons and type I interferon with distinct interferon pathways in dermatomyositis, systemic lupus erythematosus and autoimmune blistering disease

Ejemplares similares