Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome

Reduction of A. muciniphila relative abundance in the gut microbiota is a widely accepted signature associated with obesity-related metabolic disorders. Using untargeted metabolomics profiling of fasting plasma, our study aimed at identifying metabolic signatures associated with beneficial propertie...

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Autores principales:	Clara Depommier, Amandine Everard, Céline Druart, Dominique Maiter, Jean-Paul Thissen, Audrey Loumaye, Michel P. Hermans, Nathalie M. Delzenne, Willem M. de Vos, Patrice D. Cani
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	a. muciniphila human obesity metabolic syndrome prediabetes metabolomic amino-acids ketone bodies acylcarnitines Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/6341d931c48a4b9ca98f643397066cb6
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spelling	oai:doaj.org-article:6341d931c48a4b9ca98f643397066cb62021-11-26T11:19:48ZSerum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome1949-09761949-098410.1080/19490976.2021.1994270https://doaj.org/article/6341d931c48a4b9ca98f643397066cb62021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/19490976.2021.1994270https://doaj.org/toc/1949-0976https://doaj.org/toc/1949-0984Reduction of A. muciniphila relative abundance in the gut microbiota is a widely accepted signature associated with obesity-related metabolic disorders. Using untargeted metabolomics profiling of fasting plasma, our study aimed at identifying metabolic signatures associated with beneficial properties of alive and pasteurized A. muciniphila when administrated to a cohort of insulin-resistant individuals with metabolic syndrome. Our data highlighted either shared or specific alterations in the metabolome according to the form of A. muciniphila administered with respect to a control group. Common responses encompassed modulation of amino acid metabolism, characterized by reduced levels of arginine and alanine, alongside several intermediates of tyrosine, phenylalanine, tryptophan, and glutathione metabolism. The global increase in levels of acylcarnitines together with specific modulation of acetoacetate also suggested induction of ketogenesis through enhanced β-oxidation. Moreover, our data pinpointed some metabolites of interest considering their emergence as substantial compounds pertaining to health and diseases in the more recent literature.Clara DepommierAmandine EverardCéline DruartDominique MaiterJean-Paul ThissenAudrey LoumayeMichel P. HermansNathalie M. DelzenneWillem M. de VosPatrice D. CaniTaylor & Francis Grouparticlea. muciniphilahumanobesitymetabolic syndromeprediabetesmetabolomicamino-acidsketone bodiesacylcarnitinesDiseases of the digestive system. GastroenterologyRC799-869ENGut Microbes, Vol 13, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	a. muciniphila human obesity metabolic syndrome prediabetes metabolomic amino-acids ketone bodies acylcarnitines Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	a. muciniphila human obesity metabolic syndrome prediabetes metabolomic amino-acids ketone bodies acylcarnitines Diseases of the digestive system. Gastroenterology RC799-869 Clara Depommier Amandine Everard Céline Druart Dominique Maiter Jean-Paul Thissen Audrey Loumaye Michel P. Hermans Nathalie M. Delzenne Willem M. de Vos Patrice D. Cani Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
description	Reduction of A. muciniphila relative abundance in the gut microbiota is a widely accepted signature associated with obesity-related metabolic disorders. Using untargeted metabolomics profiling of fasting plasma, our study aimed at identifying metabolic signatures associated with beneficial properties of alive and pasteurized A. muciniphila when administrated to a cohort of insulin-resistant individuals with metabolic syndrome. Our data highlighted either shared or specific alterations in the metabolome according to the form of A. muciniphila administered with respect to a control group. Common responses encompassed modulation of amino acid metabolism, characterized by reduced levels of arginine and alanine, alongside several intermediates of tyrosine, phenylalanine, tryptophan, and glutathione metabolism. The global increase in levels of acylcarnitines together with specific modulation of acetoacetate also suggested induction of ketogenesis through enhanced β-oxidation. Moreover, our data pinpointed some metabolites of interest considering their emergence as substantial compounds pertaining to health and diseases in the more recent literature.
format	article
author	Clara Depommier Amandine Everard Céline Druart Dominique Maiter Jean-Paul Thissen Audrey Loumaye Michel P. Hermans Nathalie M. Delzenne Willem M. de Vos Patrice D. Cani
author_facet	Clara Depommier Amandine Everard Céline Druart Dominique Maiter Jean-Paul Thissen Audrey Loumaye Michel P. Hermans Nathalie M. Delzenne Willem M. de Vos Patrice D. Cani
author_sort	Clara Depommier
title	Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
title_short	Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
title_full	Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
title_fullStr	Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
title_full_unstemmed	Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
title_sort	serum metabolite profiling yields insights into health promoting effect of a. muciniphila in human volunteers with a metabolic syndrome
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/6341d931c48a4b9ca98f643397066cb6
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Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome

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