The bright side of fibroblasts: molecular signature and regenerative cues in major organs

Abstract Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, ac...

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Autores principales:	Rita N. Gomes, Filipa Manuel, Diana S. Nascimento
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/6346be79c53e483da95b01693d5584a5
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spelling	oai:doaj.org-article:6346be79c53e483da95b01693d5584a52021-12-02T15:08:41ZThe bright side of fibroblasts: molecular signature and regenerative cues in major organs10.1038/s41536-021-00153-z2057-3995https://doaj.org/article/6346be79c53e483da95b01693d5584a52021-08-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00153-zhttps://doaj.org/toc/2057-3995Abstract Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, accumulating evidence supports a pro-regenerative role of fibroblasts in different organs. While some organs rely on fibroblasts for maintaining stem cell niches, others depend on fibroblast activity, particularly on secreted molecules that promote cell adhesion, migration, and proliferation, to guide the regenerative process. Herein we provide an up-to-date overview of fibroblast-derived regenerative signaling across different organs and discuss how this capacity may become compromised with aging. We further introduce a new paradigm for regenerative therapies based on reverting adult fibroblasts to a fetal/neonatal-like phenotype.Rita N. GomesFilipa ManuelDiana S. NascimentoNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Rita N. Gomes Filipa Manuel Diana S. Nascimento The bright side of fibroblasts: molecular signature and regenerative cues in major organs
description	Abstract Fibrosis is a pathologic process characterized by the replacement of parenchymal tissue by large amounts of extracellular matrix, which may lead to organ dysfunction and even death. Fibroblasts are classically associated to fibrosis and tissue repair, and seldom to regeneration. However, accumulating evidence supports a pro-regenerative role of fibroblasts in different organs. While some organs rely on fibroblasts for maintaining stem cell niches, others depend on fibroblast activity, particularly on secreted molecules that promote cell adhesion, migration, and proliferation, to guide the regenerative process. Herein we provide an up-to-date overview of fibroblast-derived regenerative signaling across different organs and discuss how this capacity may become compromised with aging. We further introduce a new paradigm for regenerative therapies based on reverting adult fibroblasts to a fetal/neonatal-like phenotype.
format	article
author	Rita N. Gomes Filipa Manuel Diana S. Nascimento
author_facet	Rita N. Gomes Filipa Manuel Diana S. Nascimento
author_sort	Rita N. Gomes
title	The bright side of fibroblasts: molecular signature and regenerative cues in major organs
title_short	The bright side of fibroblasts: molecular signature and regenerative cues in major organs
title_full	The bright side of fibroblasts: molecular signature and regenerative cues in major organs
title_fullStr	The bright side of fibroblasts: molecular signature and regenerative cues in major organs
title_full_unstemmed	The bright side of fibroblasts: molecular signature and regenerative cues in major organs
title_sort	bright side of fibroblasts: molecular signature and regenerative cues in major organs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6346be79c53e483da95b01693d5584a5
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The bright side of fibroblasts: molecular signature and regenerative cues in major organs

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