Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

Abstract Background Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of tumors. However, its association with nephrotoxicity limits its therapeutic use. Ocimum gratissimum leaf is a medicinal plant with numerous pharmacological and thera...

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Autores principales:	Quadri K. Alabi, Rufus O. Akomolafe, Joseph G. Omole, Ayodeji Aturamu, Mokolade S. Ige, Oyindasola O. Kayode, Deborah Kajewole-Alabi
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Antioxidant Creatinine Cyclophosphamid Ocimum gratissimum leaf Kidney Sodium Other systems of medicine RZ201-999
Acceso en línea:	https://doaj.org/article/6347498abab4437b8ebadf35d9cc3e2e
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spelling	oai:doaj.org-article:6347498abab4437b8ebadf35d9cc3e2e2021-11-08T11:14:02ZPolyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats10.1186/s12906-021-03447-32662-7671https://doaj.org/article/6347498abab4437b8ebadf35d9cc3e2e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12906-021-03447-3https://doaj.org/toc/2662-7671Abstract Background Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of tumors. However, its association with nephrotoxicity limits its therapeutic use. Ocimum gratissimum leaf is a medicinal plant with numerous pharmacological and therapeutic efficacies, such as antioxidant, anti-inflammation, and anti-apoptotic properties. Methods The present study was designed to evaluate the protective effect of Ocimum gratissimum (OG) against CP-induced kidney dysfunction in rats. Rats were pre-treated with 400 mg/kg b.w. of leave extract of Ocimum gratissimum (Ocimum G.) for 4 days and then 50 mg/kg b.w. of CP was co-administered from day 5 to day 7 along with Ocimum G. Markers of renal function and oxidative stress, food and water intake, electrolytes, aldosterone, leukocytes infiltration, inflammation and histopathological alteration were evaluated. Results Obvious renal inflammation and kidney injuries were observed in CP treated groups. However, administration of leave extract of Ocimum G. prevented oxidative stress, kidney injuries, attenuated inflammation, increased aldosterone production and reduced sodium ion and water loss in rats. The plasma creatinine, urea and urine albumin concentration were normalized after the administration of Ocimum G. extract in rats treated with CP. Ocimum G. also decreased the plasma concentrations of Interleukin-(IL)-6, C-reactive protein and activity of myeloperoxidase and malondialdehyde in CP treated rats. Conclusion Ocimum G. prevented kidney injury and enhanced renal function via inhibiting inflammation and oxidant-induced CP toxicity. The efficacy of Ocimum G. is related to the presence of various phytochemicals in the plant.Quadri K. AlabiRufus O. AkomolafeJoseph G. OmoleAyodeji AturamuMokolade S. IgeOyindasola O. KayodeDeborah Kajewole-AlabiBMCarticleAntioxidantCreatinineCyclophosphamidOcimum gratissimum leafKidneySodiumOther systems of medicineRZ201-999ENBMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antioxidant Creatinine Cyclophosphamid Ocimum gratissimum leaf Kidney Sodium Other systems of medicine RZ201-999
spellingShingle	Antioxidant Creatinine Cyclophosphamid Ocimum gratissimum leaf Kidney Sodium Other systems of medicine RZ201-999 Quadri K. Alabi Rufus O. Akomolafe Joseph G. Omole Ayodeji Aturamu Mokolade S. Ige Oyindasola O. Kayode Deborah Kajewole-Alabi Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
description	Abstract Background Cyclophosphamide (CP) is one of the potent and low cost chemotherapy used in clinical setting against a variety of tumors. However, its association with nephrotoxicity limits its therapeutic use. Ocimum gratissimum leaf is a medicinal plant with numerous pharmacological and therapeutic efficacies, such as antioxidant, anti-inflammation, and anti-apoptotic properties. Methods The present study was designed to evaluate the protective effect of Ocimum gratissimum (OG) against CP-induced kidney dysfunction in rats. Rats were pre-treated with 400 mg/kg b.w. of leave extract of Ocimum gratissimum (Ocimum G.) for 4 days and then 50 mg/kg b.w. of CP was co-administered from day 5 to day 7 along with Ocimum G. Markers of renal function and oxidative stress, food and water intake, electrolytes, aldosterone, leukocytes infiltration, inflammation and histopathological alteration were evaluated. Results Obvious renal inflammation and kidney injuries were observed in CP treated groups. However, administration of leave extract of Ocimum G. prevented oxidative stress, kidney injuries, attenuated inflammation, increased aldosterone production and reduced sodium ion and water loss in rats. The plasma creatinine, urea and urine albumin concentration were normalized after the administration of Ocimum G. extract in rats treated with CP. Ocimum G. also decreased the plasma concentrations of Interleukin-(IL)-6, C-reactive protein and activity of myeloperoxidase and malondialdehyde in CP treated rats. Conclusion Ocimum G. prevented kidney injury and enhanced renal function via inhibiting inflammation and oxidant-induced CP toxicity. The efficacy of Ocimum G. is related to the presence of various phytochemicals in the plant.
format	article
author	Quadri K. Alabi Rufus O. Akomolafe Joseph G. Omole Ayodeji Aturamu Mokolade S. Ige Oyindasola O. Kayode Deborah Kajewole-Alabi
author_facet	Quadri K. Alabi Rufus O. Akomolafe Joseph G. Omole Ayodeji Aturamu Mokolade S. Ige Oyindasola O. Kayode Deborah Kajewole-Alabi
author_sort	Quadri K. Alabi
title	Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
title_short	Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
title_full	Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
title_fullStr	Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
title_full_unstemmed	Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats
title_sort	polyphenol-rich extract of ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of wistar rats
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6347498abab4437b8ebadf35d9cc3e2e
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Polyphenol-rich extract of Ocimum gratissimum leaves prevented toxic effects of cyclophosphamide on the kidney function of Wistar rats

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