The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery

John Hovanesian,1 Alice Epitropoulos,2 Eric D Donnenfeld,3 Jack T Holladay4 1Harvard Eye Associates, Laguna Hills, CA, USA; 2Ophthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA; 3Ophthalmic Consultants of Long Island, Garden City, NY, USA; 4Baylor College of Medicine, Houston, TX, U...

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Autores principales: Hovanesian J, Epitropoulos A, Donnenfeld ED, Holladay JT
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Lenguaje:EN
Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:634c331085bf4279aaa69a386960a92f2021-12-02T11:05:58ZThe Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery1177-5483https://doaj.org/article/634c331085bf4279aaa69a386960a92f2020-09-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-lifitegrast-on-refractive-accuracy-and-symptoms-in-dry-e-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483John Hovanesian,1 Alice Epitropoulos,2 Eric D Donnenfeld,3 Jack T Holladay4 1Harvard Eye Associates, Laguna Hills, CA, USA; 2Ophthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA; 3Ophthalmic Consultants of Long Island, Garden City, NY, USA; 4Baylor College of Medicine, Houston, TX, USACorrespondence: John HovanesianHarvard Eye Associates, 24401 Calle De La Louisa, Laguna Hills, CA 92653, USATel +1 949 951 2020Fax +1 949 951 9244Email jhovanesian@harvardeye.comPurpose: To determine the effect of lifitegrast ophthalmic solution 5% on improving the tear film, biometry/keratometry, and refractive accuracy for dry eye patients scheduled for cataract surgery.Patients and Methods: Multicenter, prospective, open-label study of 100 eyes of 100 patients undergoing cataract surgery who had a confirmed diagnosis of dry eye. Patients underwent biometry at baseline and again after a 28-day course of lifitegrast 5% BID. Primary outcome was an improvement in the accuracy of preoperative anterior corneal power measurements at predicting postoperative spherical equivalent (SE) pre- and post-lifitegrast treatment. Secondary outcomes included changes in dry eye symptoms and corneal staining.Results: The accuracy of the biometry readings for the achieved refractive SE: within 0.25 D in 47% and 50% of eyes before and after the initial lifitegrast treatment, respectively; within 0.5 D in 71% and 79% of eyes before and after the initial lifitegrast treatment; and within 0.75 D in 81% and 91% of eyes before and after the initial lifitegrast treatment (p < 0.04).Conclusion: Lifitegrast 5% significantly improved preoperative corneal surface measurement accuracy in patients with confirmed dry eye who were scheduled for cataract surgery.Keywords: cataract surgery, dry eye, lifitegrast, higher-order aberrationsHovanesian JEpitropoulos ADonnenfeld EDHolladay JTDove Medical Pressarticlecataract surgerydry eyelifitegrasthigher-order aberrationsOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2709-2716 (2020)
institution DOAJ
collection DOAJ
language EN
topic cataract surgery
dry eye
lifitegrast
higher-order aberrations
Ophthalmology
RE1-994
spellingShingle cataract surgery
dry eye
lifitegrast
higher-order aberrations
Ophthalmology
RE1-994
Hovanesian J
Epitropoulos A
Donnenfeld ED
Holladay JT
The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
description John Hovanesian,1 Alice Epitropoulos,2 Eric D Donnenfeld,3 Jack T Holladay4 1Harvard Eye Associates, Laguna Hills, CA, USA; 2Ophthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA; 3Ophthalmic Consultants of Long Island, Garden City, NY, USA; 4Baylor College of Medicine, Houston, TX, USACorrespondence: John HovanesianHarvard Eye Associates, 24401 Calle De La Louisa, Laguna Hills, CA 92653, USATel +1 949 951 2020Fax +1 949 951 9244Email jhovanesian@harvardeye.comPurpose: To determine the effect of lifitegrast ophthalmic solution 5% on improving the tear film, biometry/keratometry, and refractive accuracy for dry eye patients scheduled for cataract surgery.Patients and Methods: Multicenter, prospective, open-label study of 100 eyes of 100 patients undergoing cataract surgery who had a confirmed diagnosis of dry eye. Patients underwent biometry at baseline and again after a 28-day course of lifitegrast 5% BID. Primary outcome was an improvement in the accuracy of preoperative anterior corneal power measurements at predicting postoperative spherical equivalent (SE) pre- and post-lifitegrast treatment. Secondary outcomes included changes in dry eye symptoms and corneal staining.Results: The accuracy of the biometry readings for the achieved refractive SE: within 0.25 D in 47% and 50% of eyes before and after the initial lifitegrast treatment, respectively; within 0.5 D in 71% and 79% of eyes before and after the initial lifitegrast treatment; and within 0.75 D in 81% and 91% of eyes before and after the initial lifitegrast treatment (p < 0.04).Conclusion: Lifitegrast 5% significantly improved preoperative corneal surface measurement accuracy in patients with confirmed dry eye who were scheduled for cataract surgery.Keywords: cataract surgery, dry eye, lifitegrast, higher-order aberrations
format article
author Hovanesian J
Epitropoulos A
Donnenfeld ED
Holladay JT
author_facet Hovanesian J
Epitropoulos A
Donnenfeld ED
Holladay JT
author_sort Hovanesian J
title The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_short The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_full The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_fullStr The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_full_unstemmed The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_sort effect of lifitegrast on refractive accuracy and symptoms in dry eye patients undergoing cataract surgery
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/634c331085bf4279aaa69a386960a92f
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