The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery

The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery

John Hovanesian,1 Alice Epitropoulos,2 Eric D Donnenfeld,3 Jack T Holladay4 1Harvard Eye Associates, Laguna Hills, CA, USA; 2Ophthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA; 3Ophthalmic Consultants of Long Island, Garden City, NY, USA; 4Baylor College of Medicine, Houston, TX, U...

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Autores principales: Hovanesian J, Epitropoulos A, Donnenfeld ED, Holladay JT
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2020
Materias:
cataract surgery
dry eye
lifitegrast
higher-order aberrations
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/634c331085bf4279aaa69a386960a92f
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spelling oai:doaj.org-article:634c331085bf4279aaa69a386960a92f2021-12-02T11:05:58ZThe Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery1177-5483https://doaj.org/article/634c331085bf4279aaa69a386960a92f2020-09-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-lifitegrast-on-refractive-accuracy-and-symptoms-in-dry-e-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483John Hovanesian,1 Alice Epitropoulos,2 Eric D Donnenfeld,3 Jack T Holladay4 1Harvard Eye Associates, Laguna Hills, CA, USA; 2Ophthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA; 3Ophthalmic Consultants of Long Island, Garden City, NY, USA; 4Baylor College of Medicine, Houston, TX, USACorrespondence: John HovanesianHarvard Eye Associates, 24401 Calle De La Louisa, Laguna Hills, CA 92653, USATel +1 949 951 2020Fax +1 949 951 9244Email jhovanesian@harvardeye.comPurpose: To determine the effect of lifitegrast ophthalmic solution 5% on improving the tear film, biometry/keratometry, and refractive accuracy for dry eye patients scheduled for cataract surgery.Patients and Methods: Multicenter, prospective, open-label study of 100 eyes of 100 patients undergoing cataract surgery who had a confirmed diagnosis of dry eye. Patients underwent biometry at baseline and again after a 28-day course of lifitegrast 5% BID. Primary outcome was an improvement in the accuracy of preoperative anterior corneal power measurements at predicting postoperative spherical equivalent (SE) pre- and post-lifitegrast treatment. Secondary outcomes included changes in dry eye symptoms and corneal staining.Results: The accuracy of the biometry readings for the achieved refractive SE: within 0.25 D in 47% and 50% of eyes before and after the initial lifitegrast treatment, respectively; within 0.5 D in 71% and 79% of eyes before and after the initial lifitegrast treatment; and within 0.75 D in 81% and 91% of eyes before and after the initial lifitegrast treatment (p < 0.04).Conclusion: Lifitegrast 5% significantly improved preoperative corneal surface measurement accuracy in patients with confirmed dry eye who were scheduled for cataract surgery.Keywords: cataract surgery, dry eye, lifitegrast, higher-order aberrationsHovanesian JEpitropoulos ADonnenfeld EDHolladay JTDove Medical Pressarticlecataract surgerydry eyelifitegrasthigher-order aberrationsOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2709-2716 (2020)
institution DOAJ
collection DOAJ
language EN
topic cataract surgery
dry eye
lifitegrast
higher-order aberrations
Ophthalmology
RE1-994
spellingShingle cataract surgery
dry eye
lifitegrast
higher-order aberrations
Ophthalmology
RE1-994
Hovanesian J
Epitropoulos A
Donnenfeld ED
Holladay JT
The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
description John Hovanesian,1 Alice Epitropoulos,2 Eric D Donnenfeld,3 Jack T Holladay4 1Harvard Eye Associates, Laguna Hills, CA, USA; 2Ophthalmic Surgeons & Consultants of Ohio, Columbus, OH, USA; 3Ophthalmic Consultants of Long Island, Garden City, NY, USA; 4Baylor College of Medicine, Houston, TX, USACorrespondence: John HovanesianHarvard Eye Associates, 24401 Calle De La Louisa, Laguna Hills, CA 92653, USATel +1 949 951 2020Fax +1 949 951 9244Email jhovanesian@harvardeye.comPurpose: To determine the effect of lifitegrast ophthalmic solution 5% on improving the tear film, biometry/keratometry, and refractive accuracy for dry eye patients scheduled for cataract surgery.Patients and Methods: Multicenter, prospective, open-label study of 100 eyes of 100 patients undergoing cataract surgery who had a confirmed diagnosis of dry eye. Patients underwent biometry at baseline and again after a 28-day course of lifitegrast 5% BID. Primary outcome was an improvement in the accuracy of preoperative anterior corneal power measurements at predicting postoperative spherical equivalent (SE) pre- and post-lifitegrast treatment. Secondary outcomes included changes in dry eye symptoms and corneal staining.Results: The accuracy of the biometry readings for the achieved refractive SE: within 0.25 D in 47% and 50% of eyes before and after the initial lifitegrast treatment, respectively; within 0.5 D in 71% and 79% of eyes before and after the initial lifitegrast treatment; and within 0.75 D in 81% and 91% of eyes before and after the initial lifitegrast treatment (p < 0.04).Conclusion: Lifitegrast 5% significantly improved preoperative corneal surface measurement accuracy in patients with confirmed dry eye who were scheduled for cataract surgery.Keywords: cataract surgery, dry eye, lifitegrast, higher-order aberrations
format article
author Hovanesian J
Epitropoulos A
Donnenfeld ED
Holladay JT
author_facet Hovanesian J
Epitropoulos A
Donnenfeld ED
Holladay JT
author_sort Hovanesian J
title The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_short The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_full The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_fullStr The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_full_unstemmed The Effect of Lifitegrast on Refractive Accuracy and Symptoms in Dry Eye Patients Undergoing Cataract Surgery
title_sort effect of lifitegrast on refractive accuracy and symptoms in dry eye patients undergoing cataract surgery
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/634c331085bf4279aaa69a386960a92f
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