Heterochronic shift in Hox-mediated activation of sonic hedgehog leads to morphological changes during fin development.

We explored the molecular mechanisms of morphological transformations of vertebrate paired fin/limb evolution by comparative gene expression profiling and functional analyses. In this study, we focused on the temporal differences of the onset of Sonic hedgehog (Shh) expression in paired appendages a...

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Autores principales: Koji Sakamoto, Koh Onimaru, Keijiro Munakata, Natsuno Suda, Mika Tamura, Haruki Ochi, Mikiko Tanaka
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2009
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Acceso en línea:https://doaj.org/article/634f361556e242b28f07d9b20ba75109
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