BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women

Zhao Ma, Yong Yang,* JiSheng Lin, XiaoDong Zhang, Qian Meng, BingQiang Wang, Qi Fei* Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Purpose: To develop a sim...

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Autores principales:	Ma Z, Yang Y, Lin JS, Zhang XD, Meng Q, Wang BQ, Fei Q
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Women Osteoporosis Osteoporosis screening tool Validation Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/635106287a9e43deab9af6a963375302
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spelling	oai:doaj.org-article:635106287a9e43deab9af6a9633753022021-12-02T06:17:16ZBFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women1178-1998https://doaj.org/article/635106287a9e43deab9af6a9633753022016-08-01T00:00:00Zhttps://www.dovepress.com/bfh-ost-a-new-predictive-screening-tool-for-identifying-osteoporosis-i-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Zhao Ma, Yong Yang,* JiSheng Lin, XiaoDong Zhang, Qian Meng, BingQiang Wang, Qi Fei* Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Purpose: To develop a simple new clinical screening tool to identify primary osteoporosis by dual-energy X-ray absorptiometry (DXA) in postmenopausal women and to compare its validity with the Osteoporosis Self-Assessment Tool for Asians (OSTA) in a Han Chinese population.Methods: A cross-sectional study was conducted, enrolling 1,721 community-dwelling postmenopausal Han Chinese women. All the subjects completed a structured questionnaire and had their bone mineral density measured using DXA. Using logistic regression analysis, we assessed the ability of numerous potential risk factors examined in the questionnaire to identify women with osteoporosis. Based on this analysis, we build a new predictive model, the Beijing Friendship Hospital Osteoporosis Self-Assessment Tool (BFH-OST). Receiver operating characteristic curves were generated to compare the validity of the new model and OSTA in identifying postmenopausal women at increased risk of primary osteoporosis as defined according to the World Health Organization criteria.Results: At screening, it was found that of the 1,721 subjects with DXA, 22.66% had osteoporosis and a further 47.36% had osteopenia. Of the items screened in the questionnaire, it was found that age, weight, height, body mass index, personal history of fracture after the age of 45 years, history of fragility fracture in either parent, current smoking, and consumption of three of more alcoholic drinks per day were all predictive of osteoporosis. However, age at menarche and menopause, years since menopause, and number of pregnancies and live births were irrelevant in this study. The logistic regression analysis and item reduction yielded a final tool (BFH-OST) based on age, body weight, height, and history of fracture after the age of 45 years. The BFH-OST index (cutoff =9.1), which performed better than OSTA, had a sensitivity of 73.6% and a specificity of 72.7% for identifying osteoporosis, with an area under the receiver operating characteristic curve of 0.797.Conclusion: BFH-OST may be a powerful and cost-effective new clinical risk assessment tool for prescreening postmenopausal women at increased risk for osteoporosis by DXA, especially for Han Chinese women. Keywords: women, osteoporosis, osteoporosis screening tool, validationMa ZYang YLin JSZhang XDMeng QWang BQFei QDove Medical PressarticleWomenOsteoporosisOsteoporosis screening toolValidationGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 1051-1059 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Women Osteoporosis Osteoporosis screening tool Validation Geriatrics RC952-954.6
spellingShingle	Women Osteoporosis Osteoporosis screening tool Validation Geriatrics RC952-954.6 Ma Z Yang Y Lin JS Zhang XD Meng Q Wang BQ Fei Q BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women
description	Zhao Ma, Yong Yang,* JiSheng Lin, XiaoDong Zhang, Qian Meng, BingQiang Wang, Qi Fei* Department of Orthopedics, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China *These authors contributed equally to this work Purpose: To develop a simple new clinical screening tool to identify primary osteoporosis by dual-energy X-ray absorptiometry (DXA) in postmenopausal women and to compare its validity with the Osteoporosis Self-Assessment Tool for Asians (OSTA) in a Han Chinese population.Methods: A cross-sectional study was conducted, enrolling 1,721 community-dwelling postmenopausal Han Chinese women. All the subjects completed a structured questionnaire and had their bone mineral density measured using DXA. Using logistic regression analysis, we assessed the ability of numerous potential risk factors examined in the questionnaire to identify women with osteoporosis. Based on this analysis, we build a new predictive model, the Beijing Friendship Hospital Osteoporosis Self-Assessment Tool (BFH-OST). Receiver operating characteristic curves were generated to compare the validity of the new model and OSTA in identifying postmenopausal women at increased risk of primary osteoporosis as defined according to the World Health Organization criteria.Results: At screening, it was found that of the 1,721 subjects with DXA, 22.66% had osteoporosis and a further 47.36% had osteopenia. Of the items screened in the questionnaire, it was found that age, weight, height, body mass index, personal history of fracture after the age of 45 years, history of fragility fracture in either parent, current smoking, and consumption of three of more alcoholic drinks per day were all predictive of osteoporosis. However, age at menarche and menopause, years since menopause, and number of pregnancies and live births were irrelevant in this study. The logistic regression analysis and item reduction yielded a final tool (BFH-OST) based on age, body weight, height, and history of fracture after the age of 45 years. The BFH-OST index (cutoff =9.1), which performed better than OSTA, had a sensitivity of 73.6% and a specificity of 72.7% for identifying osteoporosis, with an area under the receiver operating characteristic curve of 0.797.Conclusion: BFH-OST may be a powerful and cost-effective new clinical risk assessment tool for prescreening postmenopausal women at increased risk for osteoporosis by DXA, especially for Han Chinese women. Keywords: women, osteoporosis, osteoporosis screening tool, validation
format	article
author	Ma Z Yang Y Lin JS Zhang XD Meng Q Wang BQ Fei Q
author_facet	Ma Z Yang Y Lin JS Zhang XD Meng Q Wang BQ Fei Q
author_sort	Ma Z
title	BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women
title_short	BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women
title_full	BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women
title_fullStr	BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women
title_full_unstemmed	BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women
title_sort	bfh-ost, a new predictive screening tool for identifying osteoporosis in postmenopausal han chinese women
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/635106287a9e43deab9af6a963375302
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BFH-OST, a new predictive screening tool for identifying osteoporosis in postmenopausal Han Chinese women

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