Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer

Abstract Background and objectives Laparoscopic colorectal surgery causes a lower stress response than open surgery. Adiponectin is mainly derived from adipocytes and has antidiabetic, antioxidative, and anti-inflammatory capabilities. The objective of the present study was to investigate the protei...

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Autores principales:	Wenjiao Shi, Jian Lou, Xiaodan Zhang, Yun Ji, Xiaojian Weng, Jianer Du
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Adiponectin Adipose tissue Laparoscopic surgery Oxidative stress Inflammatory response Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/6352f12b685e4dadb1f9fb8d8b57fe82
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spelling	oai:doaj.org-article:6352f12b685e4dadb1f9fb8d8b57fe822021-11-21T12:40:38ZAdipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer10.1186/s12944-021-01595-61476-511Xhttps://doaj.org/article/6352f12b685e4dadb1f9fb8d8b57fe822021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01595-6https://doaj.org/toc/1476-511XAbstract Background and objectives Laparoscopic colorectal surgery causes a lower stress response than open surgery. Adiponectin is mainly derived from adipocytes and has antidiabetic, antioxidative, and anti-inflammatory capabilities. The objective of the present study was to investigate the protein expression of adiponectin in adipose tissue, and the serum levels of adiponectin, oxidative stress markers and proinflammatory factors during laparoscopic colorectal surgery and open surgery periods. Methods Forty patients aged 60 to 80, with American Society of Anesthesiologists (ASA) I ~ II who underwent radical resection of colorectal cancer were recruited to the study. Laparoscopic group and open group included 20 patients each. Mesenteric adipose tissue and venous blood before (T1) and at the end (T2) of surgery were collected to examine adiponectin levels, and venous blood was collected to examine serum levels of oxidative stress related markers (superoxide dismutase (SOD), glutathione (GSH), lipid peroxide (LPO), malondialdehyde (MDA)), and inflammation-related factors (interleukin (IL)-1β, interleukin (IL)-6, tumor necrosis factor-α (TNF-α)). Results Protein and serum levels of adiponectin were analyzed, and adiponectin levels were significantly increased at T2 than T1 in the laparoscopic surgery, while adiponectin levels were significantly higher in the laparoscopic surgery than in the open surgery at T2. In addition, the serum levels of SOD and GSH were significantly higher in the laparoscopic surgery than in open surgery at T2. However, the serum levels of LPO, TNF-α, IL-1β, and IL-6 were significantly lower in the laparoscopic group than in open group at T2. Conclusion Laparoscopic surgery induced higher levels of adiponectin in both adipose tissue and the bloodstream. Oxidative stress and the inflammatory response were lower during laparoscopic colorectal surgery than during conventional open surgery. These data suggest that adipose tissue may alleviate the stress response during laparoscopic surgery by releasing adiponectin in patients with colorectal cancer.Wenjiao ShiJian LouXiaodan ZhangYun JiXiaojian WengJianer DuBMCarticleAdiponectinAdipose tissueLaparoscopic surgeryOxidative stressInflammatory responseNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Adiponectin Adipose tissue Laparoscopic surgery Oxidative stress Inflammatory response Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Adiponectin Adipose tissue Laparoscopic surgery Oxidative stress Inflammatory response Nutritional diseases. Deficiency diseases RC620-627 Wenjiao Shi Jian Lou Xiaodan Zhang Yun Ji Xiaojian Weng Jianer Du Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
description	Abstract Background and objectives Laparoscopic colorectal surgery causes a lower stress response than open surgery. Adiponectin is mainly derived from adipocytes and has antidiabetic, antioxidative, and anti-inflammatory capabilities. The objective of the present study was to investigate the protein expression of adiponectin in adipose tissue, and the serum levels of adiponectin, oxidative stress markers and proinflammatory factors during laparoscopic colorectal surgery and open surgery periods. Methods Forty patients aged 60 to 80, with American Society of Anesthesiologists (ASA) I ~ II who underwent radical resection of colorectal cancer were recruited to the study. Laparoscopic group and open group included 20 patients each. Mesenteric adipose tissue and venous blood before (T1) and at the end (T2) of surgery were collected to examine adiponectin levels, and venous blood was collected to examine serum levels of oxidative stress related markers (superoxide dismutase (SOD), glutathione (GSH), lipid peroxide (LPO), malondialdehyde (MDA)), and inflammation-related factors (interleukin (IL)-1β, interleukin (IL)-6, tumor necrosis factor-α (TNF-α)). Results Protein and serum levels of adiponectin were analyzed, and adiponectin levels were significantly increased at T2 than T1 in the laparoscopic surgery, while adiponectin levels were significantly higher in the laparoscopic surgery than in the open surgery at T2. In addition, the serum levels of SOD and GSH were significantly higher in the laparoscopic surgery than in open surgery at T2. However, the serum levels of LPO, TNF-α, IL-1β, and IL-6 were significantly lower in the laparoscopic group than in open group at T2. Conclusion Laparoscopic surgery induced higher levels of adiponectin in both adipose tissue and the bloodstream. Oxidative stress and the inflammatory response were lower during laparoscopic colorectal surgery than during conventional open surgery. These data suggest that adipose tissue may alleviate the stress response during laparoscopic surgery by releasing adiponectin in patients with colorectal cancer.
format	article
author	Wenjiao Shi Jian Lou Xiaodan Zhang Yun Ji Xiaojian Weng Jianer Du
author_facet	Wenjiao Shi Jian Lou Xiaodan Zhang Yun Ji Xiaojian Weng Jianer Du
author_sort	Wenjiao Shi
title	Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
title_short	Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
title_full	Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
title_fullStr	Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
title_full_unstemmed	Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
title_sort	adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer
publisher	BMC
publishDate	2021
url	https://doaj.org/article/6352f12b685e4dadb1f9fb8d8b57fe82
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Adipose tissue alleviates the stress response by releasing adiponectin during laparoscopic surgery in patients with colorectal cancer

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