A cancer stem cell model as the point of origin of cancer-associated fibroblasts in tumor microenvironment

Abstract Cancer-associated fibroblasts (CAFs) are one of the most prominent cell types in the stromal compartment of the tumor microenvironment. CAFs support multiple aspects of cancer progression, including tumor initiation, invasion, and metastasis. The heterogeneous nature of the stromal microenv...

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Main Authors: Neha Nair, Anna Sanchez Calle, Maram Hussein Zahra, Marta Prieto-Vila, Aung Ko Ko Oo, Laura Hurley, Arun Vaidyanath, Akimasa Seno, Junko Masuda, Yoshiaki Iwasaki, Hiromi Tanaka, Tomonari Kasai, Masaharu Seno
Format: article
Language:EN
Published: Nature Portfolio 2017
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Online Access:https://doaj.org/article/63542ceb2b9e4c0181ab0651968d562c
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