The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo
Poised enhancers (PEs) in embryonic stem cells have accessible chromatin, are bound by repressive Polycomb Group proteins, and interact with their targets prior to activation. However, whether this is recapitulated in vivo is unknown. Here the authors show PEs display these features in mouse embryos...
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Nature Portfolio
2021
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oai:doaj.org-article:63558f435dcb4a0498df455068ac08d22021-12-02T18:36:59ZThe chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo10.1038/s41467-021-24641-42041-1723https://doaj.org/article/63558f435dcb4a0498df455068ac08d22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24641-4https://doaj.org/toc/2041-1723Poised enhancers (PEs) in embryonic stem cells have accessible chromatin, are bound by repressive Polycomb Group proteins, and interact with their targets prior to activation. However, whether this is recapitulated in vivo is unknown. Here the authors show PEs display these features in mouse embryos, are prevalent across vertebrates, and are required for developmental gene expression.Giuliano CrispatzuRizwan RehimiTomas PachanoTore BleckwehlSara Cruz-MolinaCally XiaoEsther MahabirHisham BazziAlvaro Rada-IglesiasNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021) |
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Science Q Giuliano Crispatzu Rizwan Rehimi Tomas Pachano Tore Bleckwehl Sara Cruz-Molina Cally Xiao Esther Mahabir Hisham Bazzi Alvaro Rada-Iglesias The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo |
| description |
Poised enhancers (PEs) in embryonic stem cells have accessible chromatin, are bound by repressive Polycomb Group proteins, and interact with their targets prior to activation. However, whether this is recapitulated in vivo is unknown. Here the authors show PEs display these features in mouse embryos, are prevalent across vertebrates, and are required for developmental gene expression. |
| format |
article |
| author |
Giuliano Crispatzu Rizwan Rehimi Tomas Pachano Tore Bleckwehl Sara Cruz-Molina Cally Xiao Esther Mahabir Hisham Bazzi Alvaro Rada-Iglesias |
| author_facet |
Giuliano Crispatzu Rizwan Rehimi Tomas Pachano Tore Bleckwehl Sara Cruz-Molina Cally Xiao Esther Mahabir Hisham Bazzi Alvaro Rada-Iglesias |
| author_sort |
Giuliano Crispatzu |
| title |
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo |
| title_short |
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo |
| title_full |
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo |
| title_fullStr |
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo |
| title_full_unstemmed |
The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo |
| title_sort |
chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/63558f435dcb4a0498df455068ac08d2 |
| work_keys_str_mv |
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1718377863186481152 |