Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level

Theresa A Koleck,1 Yvette P Conley2 1School of Nursing, 2Department of Human Genetics, School of Nursing and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA Abstract: Research is beginning to suggest that the presence and/or severity of symptoms reported by breast ca...

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Autores principales:	Koleck TA, Conley YP
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	breast neoplasms biological markers genes signs and symptoms cognition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/6356cb2b6e7248f6835a13f691af8e8b
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spelling	oai:doaj.org-article:6356cb2b6e7248f6835a13f691af8e8b2021-12-02T08:30:46ZIdentification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level1179-1314https://doaj.org/article/6356cb2b6e7248f6835a13f691af8e8b2016-03-01T00:00:00Zhttps://www.dovepress.com/identification-and-prioritization-of-candidate-genes-for-symptom-varia-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Theresa A Koleck,1 Yvette P Conley2 1School of Nursing, 2Department of Human Genetics, School of Nursing and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA Abstract: Research is beginning to suggest that the presence and/or severity of symptoms reported by breast cancer survivors may be associated with disease-related factors of cancer. In this article, we present a novel approach to the identification and prioritization of biologically plausible candidate genes to investigate relationships between genomic variation and symptom variability in breast cancer survivors. Cognitive dysfunction is utilized as a representative breast cancer survivor symptom to elucidate the conceptualization of and justification for our cellular, disease-based approach to address symptom variability in cancer survivors. Initial candidate gene identification was based on genes evaluated as part of multigene expression profiles for breast cancer, which are commonly used in the clinical setting to characterize the biology of cancer cells for the purpose of describing overall tumor aggressiveness, prognostication, and individualization of therapy. A list of genes evaluated within five multigene expression profiles for breast cancer was compiled. In order to prioritize candidate genes for investigation, genes used in each profile were compared for duplication. Twenty-one genes (BAG1, BCL2, BIRC5, CCNB1, CENPA, CMC2, DIAPH3, ERBB2, ESR1, GRB7, MELK, MKI67, MMP11, MYBL2, NDC80, ORC6, PGR, RACGAP1, RFC4, RRM2, and SCUBE2) are utilized in two or more profiles, including five genes (CCNB1, CENPA, MELK, MYBL2, and ORC6) used in three profiles. To ensure that the parsimonious 21 gene set is representative of the more global biological hallmarks of cancer, an Ingenuity Pathway Analysis was conducted. Evaluation of genes known to impact pathways involved with cancer development and progression provide a means to evaluate the overlap between the biological underpinnings of cancer and symptom development within the context of cancer. Keywords: breast neoplasms, biological markers, genes, signs and symptoms, cognitionKoleck TAConley YPDove Medical Pressarticlebreast neoplasmsbiological markersgenessigns and symptomscognitionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 29-37 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast neoplasms biological markers genes signs and symptoms cognition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	breast neoplasms biological markers genes signs and symptoms cognition Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Koleck TA Conley YP Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level
description	Theresa A Koleck,1 Yvette P Conley2 1School of Nursing, 2Department of Human Genetics, School of Nursing and Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA Abstract: Research is beginning to suggest that the presence and/or severity of symptoms reported by breast cancer survivors may be associated with disease-related factors of cancer. In this article, we present a novel approach to the identification and prioritization of biologically plausible candidate genes to investigate relationships between genomic variation and symptom variability in breast cancer survivors. Cognitive dysfunction is utilized as a representative breast cancer survivor symptom to elucidate the conceptualization of and justification for our cellular, disease-based approach to address symptom variability in cancer survivors. Initial candidate gene identification was based on genes evaluated as part of multigene expression profiles for breast cancer, which are commonly used in the clinical setting to characterize the biology of cancer cells for the purpose of describing overall tumor aggressiveness, prognostication, and individualization of therapy. A list of genes evaluated within five multigene expression profiles for breast cancer was compiled. In order to prioritize candidate genes for investigation, genes used in each profile were compared for duplication. Twenty-one genes (BAG1, BCL2, BIRC5, CCNB1, CENPA, CMC2, DIAPH3, ERBB2, ESR1, GRB7, MELK, MKI67, MMP11, MYBL2, NDC80, ORC6, PGR, RACGAP1, RFC4, RRM2, and SCUBE2) are utilized in two or more profiles, including five genes (CCNB1, CENPA, MELK, MYBL2, and ORC6) used in three profiles. To ensure that the parsimonious 21 gene set is representative of the more global biological hallmarks of cancer, an Ingenuity Pathway Analysis was conducted. Evaluation of genes known to impact pathways involved with cancer development and progression provide a means to evaluate the overlap between the biological underpinnings of cancer and symptom development within the context of cancer. Keywords: breast neoplasms, biological markers, genes, signs and symptoms, cognition
format	article
author	Koleck TA Conley YP
author_facet	Koleck TA Conley YP
author_sort	Koleck TA
title	Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level
title_short	Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level
title_full	Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level
title_fullStr	Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level
title_full_unstemmed	Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level
title_sort	identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/6356cb2b6e7248f6835a13f691af8e8b
work_keys_str_mv	AT koleckta identificationandprioritizationofcandidategenesforsymptomvariabilityinbreastcancersurvivorsbasedondiseasecharacteristicsatthecellularlevel AT conleyyp identificationandprioritizationofcandidategenesforsymptomvariabilityinbreastcancersurvivorsbasedondiseasecharacteristicsatthecellularlevel
_version_	1718398489203834880

Identification and prioritization of candidate genes for symptom variability in breast cancer survivors based on disease characteristics at the cellular level

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