High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products

The process of cheese-making has long been part of human food culture and nowadays dairy represents a large sector of the food industry. Being the main byproduct of cheese-making, the revalorization of milk whey is nowadays one of the primary goals in alignment with the principles of the circular ec...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Carmela Maria Montone, Sara Elsa Aita, Chiara Cavaliere, Andrea Cerrato, Aldo Laganà, Susy Piovesana, Anna Laura Capriotti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	whey short-chain peptides cheese-making industry suspect screening peptidomics Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/63599bb8db8847238c61dfdbd8757906
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:63599bb8db8847238c61dfdbd8757906
record_format	dspace
spelling	oai:doaj.org-article:63599bb8db8847238c61dfdbd87579062021-11-11T18:28:44ZHigh-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products10.3390/molecules262164721420-3049https://doaj.org/article/63599bb8db8847238c61dfdbd87579062021-10-01T00:00:00Zhttps://www.mdpi.com/1420-3049/26/21/6472https://doaj.org/toc/1420-3049The process of cheese-making has long been part of human food culture and nowadays dairy represents a large sector of the food industry. Being the main byproduct of cheese-making, the revalorization of milk whey is nowadays one of the primary goals in alignment with the principles of the circular economy. In the present paper, a deep and detailed investigation of short endogenous peptides in milk and its byproducts (whole whey, skimmed whey, and whey permeate) was carried out by high-resolution mass spectrometry, with a dedicated suspect screening data acquisition and data analysis approach. A total of 79 short peptides was tentatively identified, including several sequences already known for their exerted biological activities. An unsupervised chemometric approach was then employed for highlighting the differences in the short peptide content among the four sets of samples. Whole and skimmed whey showed not merely a higher content of short bioactive peptides compared to whole milk, but also a peculiar composition of peptides that are likely generated during the process of cheese-making. The results clearly demonstrate that whey represents a valuable source of bioactive compounds and that the set-up of processes of revalorization of milk byproducts is a promising path in the obtention of high revenue-generating products from dairy industrial waste.Carmela Maria MontoneSara Elsa AitaChiara CavaliereAndrea CerratoAldo LaganàSusy PiovesanaAnna Laura CapriottiMDPI AGarticlewheyshort-chain peptidescheese-making industrysuspect screeningpeptidomicsOrganic chemistryQD241-441ENMolecules, Vol 26, Iss 6472, p 6472 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	whey short-chain peptides cheese-making industry suspect screening peptidomics Organic chemistry QD241-441
spellingShingle	whey short-chain peptides cheese-making industry suspect screening peptidomics Organic chemistry QD241-441 Carmela Maria Montone Sara Elsa Aita Chiara Cavaliere Andrea Cerrato Aldo Laganà Susy Piovesana Anna Laura Capriotti High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products
description	The process of cheese-making has long been part of human food culture and nowadays dairy represents a large sector of the food industry. Being the main byproduct of cheese-making, the revalorization of milk whey is nowadays one of the primary goals in alignment with the principles of the circular economy. In the present paper, a deep and detailed investigation of short endogenous peptides in milk and its byproducts (whole whey, skimmed whey, and whey permeate) was carried out by high-resolution mass spectrometry, with a dedicated suspect screening data acquisition and data analysis approach. A total of 79 short peptides was tentatively identified, including several sequences already known for their exerted biological activities. An unsupervised chemometric approach was then employed for highlighting the differences in the short peptide content among the four sets of samples. Whole and skimmed whey showed not merely a higher content of short bioactive peptides compared to whole milk, but also a peculiar composition of peptides that are likely generated during the process of cheese-making. The results clearly demonstrate that whey represents a valuable source of bioactive compounds and that the set-up of processes of revalorization of milk byproducts is a promising path in the obtention of high revenue-generating products from dairy industrial waste.
format	article
author	Carmela Maria Montone Sara Elsa Aita Chiara Cavaliere Andrea Cerrato Aldo Laganà Susy Piovesana Anna Laura Capriotti
author_facet	Carmela Maria Montone Sara Elsa Aita Chiara Cavaliere Andrea Cerrato Aldo Laganà Susy Piovesana Anna Laura Capriotti
author_sort	Carmela Maria Montone
title	High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products
title_short	High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products
title_full	High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products
title_fullStr	High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products
title_full_unstemmed	High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products
title_sort	high-resolution mass spectrometry and chemometrics for the detailed characterization of short endogenous peptides in milk by-products
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/63599bb8db8847238c61dfdbd8757906
work_keys_str_mv	AT carmelamariamontone highresolutionmassspectrometryandchemometricsforthedetailedcharacterizationofshortendogenouspeptidesinmilkbyproducts AT saraelsaaita highresolutionmassspectrometryandchemometricsforthedetailedcharacterizationofshortendogenouspeptidesinmilkbyproducts AT chiaracavaliere highresolutionmassspectrometryandchemometricsforthedetailedcharacterizationofshortendogenouspeptidesinmilkbyproducts AT andreacerrato highresolutionmassspectrometryandchemometricsforthedetailedcharacterizationofshortendogenouspeptidesinmilkbyproducts AT aldolagana highresolutionmassspectrometryandchemometricsforthedetailedcharacterizationofshortendogenouspeptidesinmilkbyproducts AT susypiovesana highresolutionmassspectrometryandchemometricsforthedetailedcharacterizationofshortendogenouspeptidesinmilkbyproducts AT annalauracapriotti highresolutionmassspectrometryandchemometricsforthedetailedcharacterizationofshortendogenouspeptidesinmilkbyproducts
_version_	1718431825058070528

High-Resolution Mass Spectrometry and Chemometrics for the Detailed Characterization of Short Endogenous Peptides in Milk By-Products

Ejemplares similares