Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR

Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recen...

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Autores principales:	Elodie Calvez, Phaithong Bounmany, Charlotte Balière, Somphavanh Somlor, Souksakhone Viengphouthong, Thonglakhone Xaybounsou, Sitsana Keosenhom, Kitphithak Fangkham, Paul T. Brey, Valérie Caro, Vincent Lacoste, Marc Grandadam
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	dengue DENV-1 epidemiology phylogeny Lao PDR Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/635de36eb4824918a157fc34ce1084c2
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spelling	oai:doaj.org-article:635de36eb4824918a157fc34ce1084c22021-11-25T18:24:41ZUsing Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR10.3390/microorganisms91122632076-2607https://doaj.org/article/635de36eb4824918a157fc34ce1084c22021-10-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2263https://doaj.org/toc/2076-2607Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 still co-circulated in the country over this period. Here, we summarize epidemiological and molecular data of DENV-1 between 2016 and 2020 in the Lao PDR. Our data highlight the continuous circulation of DENV-1 in the country at levels ranging from 16% to 22% among serotyping tests. In addition, the phylogenetic analysis has revealed the circulation of DENV-1 genotype I at least since 2008 with a co-circulation of different clusters. Sequence data support independent DENV-1 introductions in the Lao PDR correlated with an active circulation of this serotype at the regional level in Southeast Asia. The maintenance of DENV-1 circulation over the last ten years supports a low level of immunity against this serotype within the Lao population. Thereby, the risk of a DENV-1 epidemic cannot be ruled out in the future, and this emphasizes the importance of maintaining an integrated surveillance approach to prevent major outbreaks.Elodie CalvezPhaithong BounmanyCharlotte BalièreSomphavanh SomlorSouksakhone ViengphouthongThonglakhone XaybounsouSitsana KeosenhomKitphithak FangkhamPaul T. BreyValérie CaroVincent LacosteMarc GrandadamMDPI AGarticledengueDENV-1epidemiologyphylogenyLao PDRBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2263, p 2263 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dengue DENV-1 epidemiology phylogeny Lao PDR Biology (General) QH301-705.5
spellingShingle	dengue DENV-1 epidemiology phylogeny Lao PDR Biology (General) QH301-705.5 Elodie Calvez Phaithong Bounmany Charlotte Balière Somphavanh Somlor Souksakhone Viengphouthong Thonglakhone Xaybounsou Sitsana Keosenhom Kitphithak Fangkham Paul T. Brey Valérie Caro Vincent Lacoste Marc Grandadam Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR
description	Since its first detection in 1979, dengue fever has been considered a major public health issue in the Lao People’s Democratic Republic (PDR). Dengue virus (DENV) serotype 1 was the cause of an epidemic in 2010–2011. Between 2012 and 2020, major outbreaks due successively to DENV-3, DENV-4 and recently DENV-2 have been recorded. However, DENV-1 still co-circulated in the country over this period. Here, we summarize epidemiological and molecular data of DENV-1 between 2016 and 2020 in the Lao PDR. Our data highlight the continuous circulation of DENV-1 in the country at levels ranging from 16% to 22% among serotyping tests. In addition, the phylogenetic analysis has revealed the circulation of DENV-1 genotype I at least since 2008 with a co-circulation of different clusters. Sequence data support independent DENV-1 introductions in the Lao PDR correlated with an active circulation of this serotype at the regional level in Southeast Asia. The maintenance of DENV-1 circulation over the last ten years supports a low level of immunity against this serotype within the Lao population. Thereby, the risk of a DENV-1 epidemic cannot be ruled out in the future, and this emphasizes the importance of maintaining an integrated surveillance approach to prevent major outbreaks.
format	article
author	Elodie Calvez Phaithong Bounmany Charlotte Balière Somphavanh Somlor Souksakhone Viengphouthong Thonglakhone Xaybounsou Sitsana Keosenhom Kitphithak Fangkham Paul T. Brey Valérie Caro Vincent Lacoste Marc Grandadam
author_facet	Elodie Calvez Phaithong Bounmany Charlotte Balière Somphavanh Somlor Souksakhone Viengphouthong Thonglakhone Xaybounsou Sitsana Keosenhom Kitphithak Fangkham Paul T. Brey Valérie Caro Vincent Lacoste Marc Grandadam
author_sort	Elodie Calvez
title	Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR
title_short	Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR
title_full	Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR
title_fullStr	Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR
title_full_unstemmed	Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR
title_sort	using background sequencing data to anticipate denv-1 circulation in the lao pdr
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/635de36eb4824918a157fc34ce1084c2
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Using Background Sequencing Data to Anticipate DENV-1 Circulation in the Lao PDR

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