The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body

Brain-derived neurotrophic factor (BDNF) represents one of the most widely studied neurotrophins because of the many mechanisms in which it is involved. Among these, a growing body of evidence indicates BDNF as a pleiotropic signaling molecule and unveils non-negligible implications in the regulatio...

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Autores principales:	Maria Carmela Di Rosa, Stefania Zimbone, Miriam Wissam Saab, Marianna Flora Tomasello
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	BDNF hypothalamus mitochondria exercise metabolism energy balance Science Q
Acceso en línea:	https://doaj.org/article/635e84d7a21343ab9035c596acfaf436
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spelling	oai:doaj.org-article:635e84d7a21343ab9035c596acfaf4362021-11-25T18:11:37ZThe Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body10.3390/life111112562075-1729https://doaj.org/article/635e84d7a21343ab9035c596acfaf4362021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1256https://doaj.org/toc/2075-1729Brain-derived neurotrophic factor (BDNF) represents one of the most widely studied neurotrophins because of the many mechanisms in which it is involved. Among these, a growing body of evidence indicates BDNF as a pleiotropic signaling molecule and unveils non-negligible implications in the regulation of energy balance. BDNF and its receptor are extensively expressed in the hypothalamus, regions where peripheral signals, associated with feeding control and metabolism activation, and are integrated to elaborate anorexigenic and orexigenic effects. Thus, BDNF coordinates adaptive responses to fluctuations in energy intake and expenditure, connecting the central nervous system with peripheral tissues, including muscle, liver, and the adipose tissue in a complex operational network. This review discusses the latest literature dealing with the involvement of BDNF in the maintenance of energy balance. We have focused on the physiological and molecular mechanisms by which BDNF: (I) controls the mitochondrial function and dynamics; (II) influences thermogenesis and tissue differentiation; (III) mediates the effects of exercise on cognitive functions; and (IV) modulates insulin sensitivity and glucose transport at the cellular level. Deepening the understanding of the mechanisms exploited to maintain energy homeostasis will lay the groundwork for the development of novel therapeutical approaches to help people to maintain a healthy mind in a healthy body.Maria Carmela Di RosaStefania ZimboneMiriam Wissam SaabMarianna Flora TomaselloMDPI AGarticleBDNFhypothalamusmitochondriaexercisemetabolismenergy balanceScienceQENLife, Vol 11, Iss 1256, p 1256 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	BDNF hypothalamus mitochondria exercise metabolism energy balance Science Q
spellingShingle	BDNF hypothalamus mitochondria exercise metabolism energy balance Science Q Maria Carmela Di Rosa Stefania Zimbone Miriam Wissam Saab Marianna Flora Tomasello The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
description	Brain-derived neurotrophic factor (BDNF) represents one of the most widely studied neurotrophins because of the many mechanisms in which it is involved. Among these, a growing body of evidence indicates BDNF as a pleiotropic signaling molecule and unveils non-negligible implications in the regulation of energy balance. BDNF and its receptor are extensively expressed in the hypothalamus, regions where peripheral signals, associated with feeding control and metabolism activation, and are integrated to elaborate anorexigenic and orexigenic effects. Thus, BDNF coordinates adaptive responses to fluctuations in energy intake and expenditure, connecting the central nervous system with peripheral tissues, including muscle, liver, and the adipose tissue in a complex operational network. This review discusses the latest literature dealing with the involvement of BDNF in the maintenance of energy balance. We have focused on the physiological and molecular mechanisms by which BDNF: (I) controls the mitochondrial function and dynamics; (II) influences thermogenesis and tissue differentiation; (III) mediates the effects of exercise on cognitive functions; and (IV) modulates insulin sensitivity and glucose transport at the cellular level. Deepening the understanding of the mechanisms exploited to maintain energy homeostasis will lay the groundwork for the development of novel therapeutical approaches to help people to maintain a healthy mind in a healthy body.
format	article
author	Maria Carmela Di Rosa Stefania Zimbone Miriam Wissam Saab Marianna Flora Tomasello
author_facet	Maria Carmela Di Rosa Stefania Zimbone Miriam Wissam Saab Marianna Flora Tomasello
author_sort	Maria Carmela Di Rosa
title	The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
title_short	The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
title_full	The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
title_fullStr	The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
title_full_unstemmed	The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body
title_sort	pleiotropic potential of bdnf beyond neurons: implication for a healthy mind in a healthy body
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/635e84d7a21343ab9035c596acfaf436
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The Pleiotropic Potential of BDNF beyond Neurons: Implication for a Healthy Mind in a Healthy Body

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