A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma
Osteosarcoma is a common malignant bone tumor with a propensity for drug resistance, recurrence, and metastasis. A growing number of studies have elucidated the dual role of pyroptosis in the development of cancer, which is a gasdermin-regulated novel inflammatory programmed cell death. However, the...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:635f923d9cf042159f26becfde076d2c2021-12-01T08:22:53ZA Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma1664-802110.3389/fgene.2021.780780https://doaj.org/article/635f923d9cf042159f26becfde076d2c2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fgene.2021.780780/fullhttps://doaj.org/toc/1664-8021Osteosarcoma is a common malignant bone tumor with a propensity for drug resistance, recurrence, and metastasis. A growing number of studies have elucidated the dual role of pyroptosis in the development of cancer, which is a gasdermin-regulated novel inflammatory programmed cell death. However, the interaction between pyroptosis and the overall survival (OS) of osteosarcoma patients is poorly understood. This study aimed to construct a prognostic model based on pyroptosis-related genes to provide new insights into the prognosis of osteosarcoma patients. We identified 46 differentially expressed pyroptosis-associated genes between osteosarcoma tissues and normal control tissues. A total of six risk genes affecting the prognosis of osteosarcoma patients were screened to form a pyroptosis-related signature by univariate and LASSO regression analysis and verified using GSE21257 as a validation cohort. Combined with other clinical characteristics, including age, gender, and metastatic status, we found that the pyroptosis-related signature score, which we named “PRS-score,” was an independent prognostic factor for patients with osteosarcoma and that a low PRS-score indicated better OS and a lower risk of metastasis. The result of ssGSEA and ESTIMATE algorithms showed that a lower PRS-score indicated higher immune scores, higher levels of tumor infiltration by immune cells, more active immune function, and lower tumor purity. In summary, we developed and validated a pyroptosis-related signature for predicting the prognosis of osteosarcoma, which may contribute to early diagnosis and immunotherapy of osteosarcoma.Yiming ZhangRong HeXuan LeiLianghao MaoPan JiangPan JiangChenlie NiZhengyu YinXinyu ZhongChen ChenQiping ZhengQiping ZhengDapeng LiFrontiers Media S.A.articleosteosarcomapyroptosisprognosisimmunotherapysurvival analysisGeneticsQH426-470ENFrontiers in Genetics, Vol 12 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
osteosarcoma pyroptosis prognosis immunotherapy survival analysis Genetics QH426-470 |
| spellingShingle |
osteosarcoma pyroptosis prognosis immunotherapy survival analysis Genetics QH426-470 Yiming Zhang Rong He Xuan Lei Lianghao Mao Pan Jiang Pan Jiang Chenlie Ni Zhengyu Yin Xinyu Zhong Chen Chen Qiping Zheng Qiping Zheng Dapeng Li A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma |
| description |
Osteosarcoma is a common malignant bone tumor with a propensity for drug resistance, recurrence, and metastasis. A growing number of studies have elucidated the dual role of pyroptosis in the development of cancer, which is a gasdermin-regulated novel inflammatory programmed cell death. However, the interaction between pyroptosis and the overall survival (OS) of osteosarcoma patients is poorly understood. This study aimed to construct a prognostic model based on pyroptosis-related genes to provide new insights into the prognosis of osteosarcoma patients. We identified 46 differentially expressed pyroptosis-associated genes between osteosarcoma tissues and normal control tissues. A total of six risk genes affecting the prognosis of osteosarcoma patients were screened to form a pyroptosis-related signature by univariate and LASSO regression analysis and verified using GSE21257 as a validation cohort. Combined with other clinical characteristics, including age, gender, and metastatic status, we found that the pyroptosis-related signature score, which we named “PRS-score,” was an independent prognostic factor for patients with osteosarcoma and that a low PRS-score indicated better OS and a lower risk of metastasis. The result of ssGSEA and ESTIMATE algorithms showed that a lower PRS-score indicated higher immune scores, higher levels of tumor infiltration by immune cells, more active immune function, and lower tumor purity. In summary, we developed and validated a pyroptosis-related signature for predicting the prognosis of osteosarcoma, which may contribute to early diagnosis and immunotherapy of osteosarcoma. |
| format |
article |
| author |
Yiming Zhang Rong He Xuan Lei Lianghao Mao Pan Jiang Pan Jiang Chenlie Ni Zhengyu Yin Xinyu Zhong Chen Chen Qiping Zheng Qiping Zheng Dapeng Li |
| author_facet |
Yiming Zhang Rong He Xuan Lei Lianghao Mao Pan Jiang Pan Jiang Chenlie Ni Zhengyu Yin Xinyu Zhong Chen Chen Qiping Zheng Qiping Zheng Dapeng Li |
| author_sort |
Yiming Zhang |
| title |
A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma |
| title_short |
A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma |
| title_full |
A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma |
| title_fullStr |
A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma |
| title_full_unstemmed |
A Novel Pyroptosis-Related Signature for Predicting Prognosis and Indicating Immune Microenvironment Features in Osteosarcoma |
| title_sort |
novel pyroptosis-related signature for predicting prognosis and indicating immune microenvironment features in osteosarcoma |
| publisher |
Frontiers Media S.A. |
| publishDate |
2021 |
| url |
https://doaj.org/article/635f923d9cf042159f26becfde076d2c |
| work_keys_str_mv |
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