Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis
Shi-Ze Lin,1,2 Yan-Kun Wu,2–4 Yun-Ai Su,2–4 Tian-Mei Si2–41Quanzhou Mental Health Center, The Third Hospital of Quanzhou, Quanzhou, Fujian Province, People’s Republic of China; 2Institute of Mental Health, Peking University Sixth Hospital, Beijing, People&...
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Dove Medical Press
2019
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oai:doaj.org-article:6360fa396d1c4d6ba2ae64c3114f1cd42021-12-02T03:35:21ZProspective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis1178-2021https://doaj.org/article/6360fa396d1c4d6ba2ae64c3114f1cd42019-06-01T00:00:00Zhttps://www.dovepress.com/prospective-memory-in-non-psychotic-first-degree-relatives-of-patients-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Shi-Ze Lin,1,2 Yan-Kun Wu,2–4 Yun-Ai Su,2–4 Tian-Mei Si2–41Quanzhou Mental Health Center, The Third Hospital of Quanzhou, Quanzhou, Fujian Province, People’s Republic of China; 2Institute of Mental Health, Peking University Sixth Hospital, Beijing, People’s Republic of China; 3National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, People’s Republic of China; 4NHC Key Laboratory of Mental Health, Peking University, Beijing, People’s Republic of ChinaAbstract: Prospective memory (PM) could be impaired in the non-psychotic first-degree relatives of patients with schizophrenia. This meta-analysis systematically examined the PM of non-psychotic first-degree relatives of patients with schizophrenia. Both Chinese and English databases were systematically searched for articles from the inception of the databases through November 13, 2018. Case-control studies of PM in non-psychotic first-degree relatives of patients with schizophrenia were included in the analyses. Confidence intervals (CIs) and standardized mean differences (SMDs) were calculated utilizing the random effects model. Four studies (n=268) that compared PM performance between non-psychotic first-degree relatives of patients with schizophrenia (n=136) and healthy controls (n=132) were included. Three studies were rated as “high quality”, while the quality of evidence of the three outcomes included in this meta-analysis was moderate. Compared with the healthy controls, the non-psychotic first-degree relatives of patients with schizophrenia showed impairments in overall PM (two studies, n=127; SMD: −0.46; 95% CI=−0.82, −0.11, P=0.01; I=0%), event-based PM (EBPM) (four studies, n=268; SMD: −0.56; 95% CI=−0.80, −0.31, P<0.00001; I=0%), and time-based PM (TBPM) (four studies, n=268; SMD: −0.66; 95% CI=−0.90, −0.41, P<0.00001; I=0%). This meta-analysis demonstrated that the overall PM, EBPM, and TBPM might be impaired in the non-psychotic first-degree relatives of patients with schizophrenia.Keywords: schizophrenia, relatives, prospective memory, endophenotypesLin SZWu YKSu YASi TMDove Medical PressarticleSchizophreniaRelativesProspective memoryEndophenotypesNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 1563-1571 (2019) |
| institution |
DOAJ |
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DOAJ |
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EN |
| topic |
Schizophrenia Relatives Prospective memory Endophenotypes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Schizophrenia Relatives Prospective memory Endophenotypes Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Lin SZ Wu YK Su YA Si TM Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis |
| description |
Shi-Ze Lin,1,2 Yan-Kun Wu,2–4 Yun-Ai Su,2–4 Tian-Mei Si2–41Quanzhou Mental Health Center, The Third Hospital of Quanzhou, Quanzhou, Fujian Province, People’s Republic of China; 2Institute of Mental Health, Peking University Sixth Hospital, Beijing, People’s Republic of China; 3National Clinical Research Center for Mental Disorders, Peking University Sixth Hospital, Beijing, People’s Republic of China; 4NHC Key Laboratory of Mental Health, Peking University, Beijing, People’s Republic of ChinaAbstract: Prospective memory (PM) could be impaired in the non-psychotic first-degree relatives of patients with schizophrenia. This meta-analysis systematically examined the PM of non-psychotic first-degree relatives of patients with schizophrenia. Both Chinese and English databases were systematically searched for articles from the inception of the databases through November 13, 2018. Case-control studies of PM in non-psychotic first-degree relatives of patients with schizophrenia were included in the analyses. Confidence intervals (CIs) and standardized mean differences (SMDs) were calculated utilizing the random effects model. Four studies (n=268) that compared PM performance between non-psychotic first-degree relatives of patients with schizophrenia (n=136) and healthy controls (n=132) were included. Three studies were rated as “high quality”, while the quality of evidence of the three outcomes included in this meta-analysis was moderate. Compared with the healthy controls, the non-psychotic first-degree relatives of patients with schizophrenia showed impairments in overall PM (two studies, n=127; SMD: −0.46; 95% CI=−0.82, −0.11, P=0.01; I=0%), event-based PM (EBPM) (four studies, n=268; SMD: −0.56; 95% CI=−0.80, −0.31, P<0.00001; I=0%), and time-based PM (TBPM) (four studies, n=268; SMD: −0.66; 95% CI=−0.90, −0.41, P<0.00001; I=0%). This meta-analysis demonstrated that the overall PM, EBPM, and TBPM might be impaired in the non-psychotic first-degree relatives of patients with schizophrenia.Keywords: schizophrenia, relatives, prospective memory, endophenotypes |
| format |
article |
| author |
Lin SZ Wu YK Su YA Si TM |
| author_facet |
Lin SZ Wu YK Su YA Si TM |
| author_sort |
Lin SZ |
| title |
Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis |
| title_short |
Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis |
| title_full |
Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis |
| title_fullStr |
Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis |
| title_full_unstemmed |
Prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis |
| title_sort |
prospective memory in non-psychotic first-degree relatives of patients with schizophrenia: a meta-analysis |
| publisher |
Dove Medical Press |
| publishDate |
2019 |
| url |
https://doaj.org/article/6360fa396d1c4d6ba2ae64c3114f1cd4 |
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